A-971432

A-971432

Ball and stick structure of A-971432
Identifiers
IUPAC name 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid
CAS Number	1240308-45-5
PubChem (CID)	46872626
ChemSpider	35523147
Chemical and physical data
Formula	C18H17Cl2NO3
Molar mass	366.238 g/mol
3D model (Jmol)	Interactive image
SMILES C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O
InChI InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23) Key:WAAWETUDFSIYSD-UHFFFAOYSA-N
(what is this?)

A-971432 is an orally bioavailable selective agonist of sphingosine-1-phosphate receptor 5 (S1PR5) discovered at AbbVie.^[1] It was discovered using high-throughput chemistry.^[2] S1P5 agonists have been proposed as an innovative mechanism for the treatment of neurodegenerative disorders such as Alzheimer's disease and lysosomal storage disorders such as Niemann–Pick disease.^[3]

References

1. WO application 2010093704, AbbVie, "Preparation of 1-benzylazetidine-3-carboxylic acid derivatives as agonists and antagonists of the S1P5 receptor", published 2010-08-19 
2. Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. 58: 9154–70. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
3. Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. 10: P281. doi:10.1016/j.jalz.2014.07.153.

External links

• Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. 23: 817–41. doi:10.1517/13543776.2013.783022. PMID 23541049.