ATP11C

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,[1][2] and for the prevention of intrahepatic cholestasis.[3]

References

  1. ↑ Siggs, O.M., Arnold, C.N., Huber, C., Pirie, E., Xia, Y., Lin, P., Nemazee, D., and Beutler, B. (2011). The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12, 434–440.
  2. ↑ Yabas, M., Teh, C.E., Frankenreiter, S., Lal, D., Roots, C.M., Whittle, B., Andrews, D.T., Zhang, Y., Teoh, N.C., Sprent, J., et al. (2011). ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol.
  3. ↑ Siggs, O.M., Schnabl, B., Webb, B., and Beutler, B. (2011). X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C. Proc Natl Acad Sci USA 108, 7890–7895.


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