C-myc internal ribosome entry site (IRES)
c-myc internal ribosome entry site (IRES) | |
---|---|
![]() | |
Predicted secondary structure and sequence conservation of IRES_c-myc | |
Identifiers | |
Symbol | IRES_c-myc |
Alt. Symbols | c-myc_IRES |
Rfam | RF00216 |
Other data | |
RNA type | Cis-reg; IRES |
Domain(s) | Eukaryota |
GO | 0043022 |
SO | 0000243 |
The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]
References
- ↑ Le Quesne, JP; Stoneley M; Fraser GA; Willis AE (2001). "Derivation of a structural model for the c-myc IRES". J Mol Biol. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.
External links
This article is issued from Wikipedia - version of the 5/11/2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.