Mincle receptor

Macrophage inducible Ca2+-dependent lectin, (abbreviated to mincle), is a member of the C-type lectin superfamily encoded by the gene CLEC4E. It is a receptor for mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM).[1][2] As a C-type lectin, the mincle receptor binds a range of carbohydrate structures, predominantly containing glucose or mannose, and play an important role in recognition of bacterial glycolipids by the immune system. Upon activation by cord factor, Mincle binds the Fc receptor FcRγ and Syk. Cord factor also binds and activates the related C-type lectin MCL.[3][4]

References

  1. ↑ Moody, DB; Matsunaga, I (2009). "Mincle is a long sought receptor for mycobacterial cord factor.". Journal of Experimental Medicine. 206: 2879–88. doi:10.1084/jem.20092533. PMID 20008525.
  2. ↑ Ishikawa, E; Ishikawa T; Morita YS; Toyonaga K; Yamada H; Takeuchi O; Kinoshita T; Akira S; Yoshikai Y; Yamasaki S (2009). "Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.". Journal of Experimental Medicine. 206: 2865–8. doi:10.1084/jem.20091750. PMID 20008526.
  3. ↑ Miyake, Y; Toyonaga K; Mori D; Kakuta S; Hoshino Y; Oyamada A; Yamada H; Ono K; Suyama M; Iwakura Y; Yoshikai Y; Yamasaki S (2013). "C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.". Immunity. 38: 1050–1062. doi:10.1016/j.immuni.2013.03.010. PMID 23602766.
  4. ↑ Richardson, Mark B.; Williams, Spencer J. (2014-06-23). "MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns". Frontiers in Immunology. 5. doi:10.3389/fimmu.2014.00288. ISSN 1664-3224. PMC 4066366Freely accessible. PMID 25002863.


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