Comedocarcinoma

Comedocarcinoma
Classification and external resources
ICD-O M8501/3

Comedocarcinoma is one kind of breast cancer which is most commonly very early-stage[1][2] which demonstrates central necrosis.[3] It is a usually a type of ductal carcinoma in situ. Comedo carcinomas are usually non-infiltrating and intraductal tumors. However, there have been accounts of comedocarcinoma which has then diversified into other cell types and developed into infiltrating (invasive) ductal carcinoma.[4] Recurrence and survival rates differ for invasive breast cancer which has originated as comedocarcinoma compared with other types of cancer cells.[5]

The duct will have characteristic necrotic tissue with calcification that feels cord-like. Squeezing the duct will yield inspissated material that is cheese-like and similar in consistency to toothpaste.

Comedocarcinoma has also been described as a histopathological type of Sebaceous carcinoma

References

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

  1. ↑ Yale: Cardiothoracic Imaging - Comedocarcinoma of the right breast Archived August 3, 2008, at the Wayback Machine.
  2. ↑ Definition: comedocarcinoma from Online Medical Dictionary
  3. ↑ Wellfire Interactive. "Pathology Thread". virginia.edu.
  4. ↑ Shahid Pervez; Hassan Khan. "Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case series". J Med Case Reports. 2007; 1: 83.
  5. ↑ Bonnier P1, Body G, Bessenay F, Charpin C, Fétissof F, Beedassy B, Lejeune C, Piana L. "Prognostic factors in ductal carcinoma in situ of the breast: results of a retrospective study of 575 cases.". Eur J Obstet Gynecol Reprod Biol. 1999 May;84(1):27-35.


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