Cyanopeptolin

Cyanopeptolins are a class of oligopeptides produced by Microcystis and Planktothrix algae strains, and can be neurotoxic.[1][2][3] The production of cyanopeptolins occurs through nonribosomal peptides synthases (NRPS).[4]

Characteristics

Increased water temperatures, because of climate change and eutrophication of inland waters promote blooms of cyanobacteria, potentially threaten water contamination by the production of the toxic cyanopeptolin (CP1020).[1]

Exposure

Cyanopeptolin (CP1020) exposure in zebrafish affected pathways related to DNA damage, the circadian rhythm and response to light.[1]

See also

References

  1. 1 2 3 Susanne Faltermann, Sara Zucchi, Esther Kohler, Judith F. Blom, Jakob Pernthaler, Karl Fent (April 2014). "Molecular effects of the cyanobacterial toxin cyanopeptolin (CP1020) occurring in algal blooms: Global transcriptome analysis in zebrafish embryos". doi:10.1016/j.aquatox.2014.01.018.
  2. ↑ Karl Gademann, Cyril Portmann, Judith F. Blom, Michael Zeder and Friedrich Jüttner (2010). "Multiple Toxin Production in the Cyanobacterium Microcystis: Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020". J. Nat. Prod. doi:10.1021/np900818c.
  3. ↑ Martin Welker and Hans Von Döhren (2006). "Cyanobacterial peptides – Nature's own combinatorial biosynthesis". FEMS Microbiology Reviews. doi:10.1111/j.1574-6976.2006.00022.x.
  4. ↑ Ramsy Agha, Samuel Cirés, Lars Wörmer and Antonio Quesada (2013). "Limited Stability of Microcystins in Oligopeptide Compositions of Microcystis aeruginosa (Cyanobacteria): Implications in the Definition of Chemotypes". Toxins. doi:10.3390/toxins5061089.

External links

Cyanobacteria, and toxin production (The New York Times)

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