Diphenidol

Diphenidol
Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral
ATC code	none
Pharmacokinetic data
Biological half-life	4 hours
Identifiers
IUPAC name 1,1-di(phenyl)-4-piperidin-1-ylbutan-1-ol
CAS Number	972-02-1^Y
PubChem (CID)	9175
IUPHAR/BPS	7163
DrugBank	DB01231^Y
ChemSpider	2947^Y
UNII	NQO8R319LY^Y
KEGG	D03858^Y
ChEBI	CHEBI:4638^Y
ChEMBL	CHEMBL936^Y
ECHA InfoCard	100.012.310
Chemical and physical data
Formula	C₂₁H₂₇NO
Molar mass	309.44518 g/mol
3D model (Jmol)	Interactive image
SMILES OC(c1ccccc1)(c2ccccc2)CCCN3CCCCC3
InChI InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2^Y Key:OGAKLTJNUQRZJU-UHFFFAOYSA-N^Y
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Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. - Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

References

DrugBank http://www.drugbank.ca/drugs/DB01231

Soto, E; Vega, R (2010). "Neuropharmacology of vestibular system disorders". Curr Neuropharmacol. 8: 26–40. doi:10.2174/157015910790909511. PMC 2866460. PMID 20808544.

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