Distributed Annotation System

The Distributed Annotation System (DAS) is an open source project that is used in bioinformatics to share and collate genomic annotation information.[1][2][3] It originated as the work of Robin Dowell, Rodney Jokerst, Allen Day, Sean Eddy and Lincoln Stein,[1] but it has since evolved into a community driven project with its main hub BioDAS. The current stable version of DAS is 2.0, which is also written as "DAS/2", whereas the older but still commonly used version 1.6 is abbreviated as "DAS/1". The latter DAS/2 specification is not compatible with DAS/1.[4]

Sites and tools currently using DAS

DAS clients

Name Description Links
BioJava DAS Client
Dasty A web client for visualizing protein sequence feature information using DAS
DasView A server-side Perl application. This tool is mentioned in the original DAS publication, but has subsequently disappeared.
EnsEMBL The EnsEMBL Genome Browser. Provides built-in support for DAS
Geodesic An stand-alone Java application
IGB The Integrated Genome Browser (IGB, pronounced "ig-bee") is an application built upon the GenoViz SDK and Genometry for visualization and exploration of genomes and corresponding annotations from multiple data sources
Jalview A multiple sequence alignment editor & viewer
OmniGene The user interface is based on the EnsEMBL interface
SIMAP Similarity Matrix of Proteins
SPICE A browser for the annotations for protein sequences and structures
STRAP Underlining sequence features in multiple alignments. Example output:
TIGR DAS Viewer
WormBase The WormBase genome Browser. Includes a DAS viewer named DASView

References

  1. 1 2 Dowell RD, Jokerst RM, Day A, Eddy SR, Stein L (2001). "The distributed annotation system.". BMC Bioinformatics. 2: 7. doi:10.1186/1471-2105-2-7. PMC 58584Freely accessible. PMID 11667947.
  2. Finn RD, Stalker JW, Jackson DK, Kulesha E, Clements J, Pettett R (2007). "ProServer: a simple, extensible Perl DAS server.". Bioinformatics. 23 (12): 1568–70. doi:10.1093/bioinformatics/btl650. PMC 2989875Freely accessible. PMID 17237073.
  3. Jenkinson AM, Albrecht M, Birney E, Blankenburg H, Down T, Finn RD, Hermjakob H, Hubbard TJ, Jimenez RC, Jones P, Kähäri A, Kulesha E, Macías JR, Reeves GA, Prlic A (2008). "Integrating biological data - the Distributed Annotation System.". BMC Bioinformatics. 9. Suppl 8: S3. doi:10.1186/1471-2105-9-S8-S3. PMC 2500094Freely accessible. PMID 18673527.
  4. The DAS/2 Protocol. BioDAS.

External links

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