Flusilazole

Flusilazole

Names
IUPAC name 1-((bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole
Other names DPX-H6573;
Identifiers
CAS Number	85509-19-9
3D model (Jmol)	Interactive image
ChEBI	CHEBI:81922
ChemSpider	66326
ECHA InfoCard	100.107.525
PubChem	73675
InChI InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 Key: FQKUGOMFVDPBIZ-UHFFFAOYSA-N InChI=1/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 Key: FQKUGOMFVDPBIZ-UHFFFAOYAI
SMILES c2ncnn2C[Si](C)(c(cc1)ccc1F)c3ccc(F)cc3
Properties
Chemical formula	C16H15F2N3Si
Density	315.392 g/cm^3
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Flusilazole (DPX-H6573) is an organosilicon fungicide invented by DuPont, which is used to control fungal infections on a variety of fruit and vegetable crops.^[1][2][3] It is moderately toxic to animals and has been shown to produce birth defects and embryotoxicity at high doses.^[4][5]

External links

• Flusilazole in the Pesticide Properties DataBase (PPDB)

References

1. Moberg, W. K.; Basarab, G. S.; Cuomo, J.; Liang, P. H. (1987). "Biologically Active Organosilicon Compounds". 355: 288. doi:10.1021/bk-1987-0355.ch026.
2. Bostanian NJ, Larocque N, Chouinard G, Coderre D (November 2001). "Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae)". Pest Management Science. 57 (11): 1007–10. doi:10.1002/ps.374. PMID 11721516.
3. Eckert MR, Rossall S, Selley A, Fitt BD (April 2010). "Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape)". Pest Management Science. 66 (4): 396–405. doi:10.1002/ps.1890. PMID 20013877.
4. Farag AT, Ibrahim HH (February 2007). "Developmental toxic effects of antifungal flusilazole administered by gavage to mice". Birth Defects Research. Part B, Developmental and Reproductive Toxicology. 80 (1): 12–7. doi:10.1002/bdrb.20098. PMID 17187383.
5. Hermsen SA, van den Brandhof EJ, van der Ven LT, Piersma AH (January 2011). "Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies". Toxicology in Vitro. 25 (3): 745–753. doi:10.1016/j.tiv.2011.01.005. PMID 21238576.