Folate-binding protein

Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.[1]

It can be a marker for ovarian cancer.[2]

It can be measured to help in tumour classification to aid treatment. FBP is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.[3]

Alternative usage

FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.[4]

References

  1. ↑ "The role of folate receptor a in cancer development, progression and treatment: Cause, consequence or innocent bystander?". Int. J. Cancer. 119 (2): 243–50. 2006. doi:10.1002/ijc.21712. PMID 16453285.
  2. ↑ "Folate-binding Protein Is a Marker for Ovarian Cancer". 1991.
  3. ↑ http://www.marketwatch.com/story/galena-biopharma-to-present-at-the-10th-annual-biotechnology-investor-forum-2011-10-21
  4. ↑ http://www.scrippslabs.com/enzymes-biochemicals-folate-binding-protein/


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