Gaines (surname)
For the unrelated Indian surname, see Gain (surname).
Gaines is a surname. Notable people with the surname include:
- Brian R. Gaines, British systems scientist and engineer
- Cassie Gaines (1948–1977), American singer; backup singer for Southern rock band Lynyrd Skynyrd, and sister of fellow band member Steve Gaines (below)
- Charles Gaines (fire chief), fire chief of Fort Worth, Texas
- Charles Gaines, Pumping Iron, Stay Hungry
- Chris Gaines (gridiron football) (born 1965), American football player
- Clarence Gaines (1923–2005), American basketball coach
- David Gaines (basketball), retired American professional basketball player
- David Gaines (composer), musician and composer
- David Gaines (race car driver), NASCAR Limited Sportsman Division race car driver
- Edmund P. Gaines (1777–1849), United States Army officer, brother of George Strother Gaines
- Ernest J. Gaines (born 1933), African American author
- George Gaines (set decorator), Academy Award winner for Best Art Direction
- George Strother Gaines (1784–1873), American leader in the Mississippi Territory, brother of Edmund P. Gaines
- Jacques Gaines, Canadian singer, lead singer of Soul Attorneys
- John P. Gaines (1795–1857), Governor of Oregan Territory
- John W. Gaines (1860–1926), U.S. Congressman from Tennessee
- Lloyd L. Gaines, (born 1911, disappeared 1939), pioneering American civil rights litigant
- Max Gaines (died 1947), pioneering American comic book publisher, father of William Gaines
- Randal Gaines (born 1955), American politician
- Reece Gaines (born 1981), American professional basketball player
- Richard Gaines (1904-1975), actor
- Rowdy Gaines (born 1959), American swimmer
- Roy Gaines (born 1934), American blues guitarist
- Sheldon Gaines (born 1964), American football player
- Steve Gaines (1949–1977), American musician, guitarist and songwriter for Southern rock band Lynyrd Skynyrd
- William Gaines (1922–1992), American publisher of EC Comics, founder of Mad magazine
- William E. Gaines (1844-1912), United States Representative (Republican), Civil War veteran
- William Gaines (professor), Pulitzer Prize-winning American journalist and professor of journalism
- Gaines A. Knapp (18448-1918), American politician
- Chris Gaines, fictional alter ego of American country music singer Garth Brooks
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