Impaired glucose tolerance

Impaired glucose tolerance
Classification and external resources
ICD-10 R73.0
ICD-9-CM 790.21
MeSH D018149

Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality.[1]

Criteria

According to the criteria of the World Health Organization and the American Diabetes Association, impaired glucose tolerance is defined as:[2][3][4]

From 10 to 15 percent of adults in the United States have impaired glucose tolerance or impaired fasting glucose.[5]

Treatment

The risk of progression to diabetes and development of cardiovascular disease is greater than for impaired fasting glucose.[6]

Although some drugs can delay the onset of diabetes, lifestyle modifications play a greater role in the prevention of diabetes.[5][7] Patients identified as having an IGT may be able to prevent diabetes through a combination of increased exercise and reduction of body weight.[5] "Drug therapy can be considered when aggressive lifestyle interventions are unsuccessful."[5]

See also

References

  1. Barr EL, Zimmet PZ, Welborn TA, et al. (2007). "Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)". Circulation. 116 (2): 151–7. doi:10.1161/CIRCULATIONAHA.106.685628. PMID 17576864.
  2. .World Health Organization. "Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus". Retrieved 2007-05-29.
  3. American Diabetes, Association (2005). "Diagnosis and classification of diabetes mellitus". Diabetes Care. 28 Suppl 1: S37–42. doi:10.2337/diacare.28.suppl_1.s37. PMID 15618111.
  4. http://www.diabetes.co.uk/impaired-glucose-tolerance.html
  5. 1 2 3 4 Shobha S. Rao; Phillip Disraeli; Tamara McGregor (15 April 2004). "Impaired Glucose Tolerance and Impaired Fasting Glucose". American Family Physician. 69 (8): 1961.
  6. Oxford Handbook of Clinical Medicine, 7th Ed., Longmore, Wilkinson, Turmezei and Cheung. Oxford University Press 2007.
  7. Raina Elley C, Kenealy T (December 2008). "Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance". Evid Based Med. 13 (6): 173. doi:10.1136/ebm.13.6.173. PMID 19043031.

Further reading

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