Pre-integration complex

The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA code into DNA code.[1] The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA.[1] The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells.[2][3] Following nuclear entry, the PIC's DNA payload may be integrated into the host DNA as a "provirus".[4]

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References

  1. 1 2 Nathalie Arhel (2010) Revisiting HIV-1 uncoating, Retrovirology
  2. ↑ Piller, S. C.; Caly, L.; Jans, D. A. (2003). "Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?". Current drug targets. 4 (5): 409–429. doi:10.2174/1389450033490984. PMID 12816349.
  3. ↑ De Rijck, J.; Vandekerckhove, L.; Christ, F.; Debyser, Z. (2007). "Lentiviral nuclear import: a complex interplay between virus and host". BioEssays. 29 (5): 441–451. doi:10.1002/bies.20561. PMID 17450594.
  4. ↑ Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology. 50 (5): 377–386. doi:10.1159/000109752. PMID 17938572.


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