Hepatitis B virus PRE beta

Hepatitis B virus PRE beta
Type: Cis-reg;
2° structure: Published; PMID 9776740[1]
Seed alignment: PMID 9776740[1]
Avg length: 23 nucleotides
Avg identity: 00%

The Hepatitis B virus PREbeta (HBV PREbeta) is an RNA structure that is shown to play a role in nuclear export of HBV mRNAs.

The minimal HBV PREbeta structure consists of a 23 nt stem-loop, with a 9 nt apical loop. The conserved stem-loop was predicted within the HBV PRE sequence and confirmed by mutagenesis.[1] The Rfam structure is based on a covariation model. The exact role of this structure in nuclear export has not been determined [2]

See also

References

  1. 1 2 3 Smith Gj, 3rd; Donello, JE; Lück, R; Steger, G; Hope, TJ (1998). "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function". Nucleic Acids Research. 26 (21): 4818–27. doi:10.1093/nar/26.21.4818. PMC 147918Freely accessible. PMID 9776740.
  2. ↑ Chen, A; Panjaworayan T-Thienprasert, N; Brown, CM (7 July 2014). "Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus.". World journal of gastroenterology : WJG. 20 (25): 7993–8004. doi:10.3748/wjg.v20.i25.7993. PMID 25009369.

External links

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