Hol44 family

The Holin Hol44 (Hol44) Family (TC# 1.E.29) is a group of transporters belonging to the Holin Superfamily V.[1] A representative list of proteins belonging to the Hol44 family from caudovirales and firmicutes can be found in the Transporter Classification Database.

One characteristic member of the Hol44 family is oenophage fOg44 (Lys44; TC# 1.E.29.2.1), which secretes an endolysin that Oenococcus oeni cells are intrinsically resistant to. Experiments with several antimicrobials support the hypothesis that the full activity of Lys44 requires sudden ion-nonspecific dissipation of the proton motive force, an event undertaken by the fOg44 holin in the phage infection context.[2]

See also

Further reading

References

  1. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059Freely accessible. PMID 23856191.
  2. Nascimento, João Gil; Guerreiro-Pereira, Maria Carolina; Costa, Sérgio Fernandes; São-José, Carlos; Santos, Mário Almeida (2008-01-01). "Nisin-triggered activity of Lys44, the secreted endolysin from Oenococcus oeni phage fOg44". Journal of Bacteriology. 190 (1): 457–461. doi:10.1128/JB.01195-07. ISSN 1098-5530. PMC 2223723Freely accessible. PMID 17981964.

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