Hyperestrogenism
| Hyperestrogenism |
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Hyperestrogenism, hyperestrogenic state, or estrogen excess, is a medical condition characterized by an excessive amount of estrogenic activity in the body.[1]
Signs and symptoms
Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic-pituitary-gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males).[1] Symptoms of the condition in women may consist of menstrual irregularities, amenorrhea, abnormal vaginal bleeding, and enlargement of the uterus and breasts.[1][2] It may also present as isosexual precocity in children[1][2] and as hypogonadism, gynecomastia, feminization, impotence, and loss of libido in males.[3] If left untreated, hyperestrogenism may increase the risk of estrogen-sensitive cancers such as breast cancer later in life.
Causes
Hyperestrogenism can be caused by ovarian tumors,[2] genetic conditions such as aromatase excess syndrome (also known as familial hyperestrogenism), or overconsumption of exogenous sources of estrogen, including medications used in hormone replacement therapy and hormonal contraception.[3] Liver cirrhosis is another cause, though through lowered metabolism of estrogen, not oversecretion or overconsumption like the aforementioned.
Treatments
Treatment may consist of surgery in the case of tumors,[1] lower doses of estrogen in the case of exogenously-mediated estrogen excess, and estrogen-suppressing medications like gonadotropin-releasing hormone analogues and progestogens. In addition, androgens may be supplemented in the case of males.
See also
- Aromatase excess syndrome
- Aromatase deficiency
- Estrogen insensitivity syndrome
- Hypoestrogenism
- Hypergonadism
- Hyperandrogenism
- Hypogonadism
- Hypoandrogenism
- Estrogen
References
- 1 2 3 4 5 Norman Lavin (1 April 2009). Manual of Endocrinology and Metabolism. Lippincott Williams & Wilkins. p. 274. ISBN 978-0-7817-6886-3. Retrieved 5 June 2012.
- 1 2 3 Ricardo V. Lloyd (14 January 2010). Endocrine Pathology:: Differential Diagnosis and Molecular Advances. Springer. p. 316. ISBN 978-1-4419-1068-4. Retrieved 5 June 2012.
- 1 2 Lewis R. Goldfrank; Neal Flomenbaum (24 March 2006). Goldfrank's Toxicologic Emergencies. McGraw-Hill Professional. p. 443. ISBN 978-0-07-147914-1. Retrieved 5 June 2012.