MESTIT1 (gene)

In molecular biology, MEST intronic transcript 1, antisense RNA (non-protein coding), also known as MESTIT1 or PEG1-AS is a long non-coding RNA. It is an imprinted gene, which is paternally expressed.^[1] In humans, it is found on chromosome 7q32, imprinted genes on chromosome 7 are believed to be involved in Russell-Silver syndrome (RSS). However, it is believed that MESTIT1 is unlikely to cause Russell-Silver syndrome as there is a lack of mutations in this gene in Russell-Silver syndrome patients.^[1][2][3][4] MESTIT1 may regulate the expression of the MEST gene.^[1]

See also

• Long noncoding RNA

References

1. Nakabayashi K, Bentley L, Hitchins MP, Mitsuya K, Meguro M, Minagawa S, et al. (2002). "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32.". Hum Mol Genet. 11 (15): 1743–56. doi:10.1093/hmg/11.15.1743. PMID 12095916.
2. Bentley L, Nakabayashi K, Monk D, Beechey C, Peters J, Birjandi Z, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.". J Med Genet. 40 (4): 249–56. doi:10.1136/jmg.40.4.249. PMC 1735416. PMID 12676894.
3. Riesewijk AM, Blagitko N, Schinzel AA, Hu L, Schulz U, Hamel BC, et al. (1998). "Evidence against a major role of PEG1/MEST in Silver-Russell syndrome.". Eur J Hum Genet. 6 (2): 114–20. doi:10.1038/sj.ejhg.5200164. PMID 9781054.
4. Kobayashi S, Uemura H, Kohda T, Nagai T, Chinen Y, Naritomi K, et al. (2001). "No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients.". Am J Med Genet. 104 (3): 225–31. doi:10.1002/ajmg.10022. PMID 11754049.

Further reading

• Meyer E, Wollmann HA, Eggermann T (2003). "Searching for genomic variants in the MESTIT1 transcript in Silver-Russell syndrome patients.". J Med Genet. 40 (5): e65. doi:10.1136/jmg.40.5.e65. PMC 1735451. PMID 12746419.
• Yamada T, Mitsuya K, Kayashima T, Yamasaki K, Ohta T, Yoshiura K, et al. (2004). "Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.". Genomics. 83 (3): 402–12. doi:10.1016/j.ygeno.2003.08.016. PMID 14962666.
• Kim KP, Thurston A, Mummery C, Ward-van Oostwaard D, Priddle H, Allegrucci C, et al. (2007). "Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines.". Genome Res. 17 (12): 1731–42. doi:10.1101/gr.6609207. PMC 2099582. PMID 17989250.