Manion may refer to:
- Daniel Anthony Manion (born 1942), United States federal judge for the United States Court of Appeals for the Seventh Circuit
- Ed Manion, American saxophone player
- Jack Manion (1877-1959), San Francisco Police Sergeant
- John Manion (born 1931), retired Canadian civil servant
- Robert James Manion (1881-1943), leader of the Conservative Party of Canada
- Manyam Zamindar of French Yanam.