Mcr1

This article is about the yeast gene. For the antibiotic resistance mechanism, see MCR-1.

MCR1 is a gene found in yeast. It is used to understand cell cycle checkpoints.[1] Researchers are working to find a way to use this gene to create anti-cancer drugs.[1]

Function

The most common function is found during the cell cycle when mutations occur because it becomes activated without phosphorylation and turns on Cds1.[2] It also works with Cdk1 to get rid of the mutations that occur. If MCR 1 is not present in the cell these check points do not work properly.[1]

References

  1. 1 2 3 Yin L, Locovei AM, D'Urso G (October 2008). "Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation". Mol. Biol. Cell. 19 (10): 4374–82. doi:10.1091/mbc.E08-01-0020. PMC 2555949Freely accessible. PMID 18667534.
  2. ↑ "MCR1 Mcr1p [Saccharomyces cerevisiae]". Entrez Gene. National Center for Biotechnology Information.
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