Motavizumab

Motavizumab

Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	RSV glycoprotein F
Clinical data
Trade names	Numax
Routes of administration	i.v.
ATC code	J06BB17 (WHO)
Pharmacokinetic data
Protein binding	None
Identifiers
CAS Number	677010-34-3
ChemSpider	none
UNII	50Y163LK8Q
KEGG	D06621
Chemical and physical data
Formula	C6476H10014N1706O2008S48
Molar mass	Approximately 148 kg/mol
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Motavizumab (proposed INN, trade name Numax) is a humanized monoclonal antibody. It is being investigated by MedImmune (today a subsidiary of AstraZeneca) for the prevention of respiratory syncytial virus infection in high-risk infants. As of September 2009, it is undergoing Phase II and III clinical trials.^[1]

In June 2010, the FDA Antiviral Drugs Advisory Committee declined to endorse MedImmune's request for licensure of Motavizumab in a 14 to 3 decision. The members of that panel cited several reasons for the decision, and many were concerned that "we're not looking at a product that has evidence of superiority in terms of efficacy" when compared to the already available monoclonal antibody Palivizumab.^[2]

In December 2010, AstraZeneca in a stock market statement stated that it would be writing down $445m (£286m) after discontinuing a key development programme for Motavizumab. The company stated that it would no longer develop Motavizumab for the prevention of respiratory syncytial virus (RSV), and as a result was withdrawing its licence application to the US Food and Drug Administration. It added that it would continue to develop Motavizumab for other treatments of RSV.^[3]

References

1. ClinicalTrials.gov
2. "FDA Panel Nixes Licensing Request for Motavizumab". Medscape. 3 June 2010. Retrieved 2014-03-02.
3. "AstraZeneca halts work on Motavizumab drug". BBC News. 21 December 2010. Retrieved 2010-12-21.

External links

• MedImmune