NP-holin family

The Neisserial Phage-associated Holin (NP-Holin) Family (TC# 1.E.22) is a family of small proteins, between 47 - 53 amino acyl residues in length, that exhibit a single N-terminal transmembrane segment (TMS).^[1] Although annotated as phage proteins or holins, NP-Holin proteins are not yet functionally characterized, thus more research is needed to confirm holin activity. A representative list of proteins belonging to the NP-Holin family can be found in the Transporter Classification Database.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology 54: 799–825.doi:10.1146/annurev.micro.54.1.799. ISSN 0066-4227.PMID 11018145.

References

1. Piekarowicz, Andrzej; Kłyz, Aneta; Majchrzak, Michał; Adamczyk-Popławska, Monika; Maugel, Timothy K.; Stein, Daniel C. (2007-01-01). "Characterization of the dsDNA prophage sequences in the genome of Neisseria gonorrhoeae and visualization of productive bacteriophage". BMC microbiology. 7: 66. doi:10.1186/1471-2180-7-66. ISSN 1471-2180. PMC 1931599. PMID 17615066.
2. "1.E.22. The Neisserial Phage-associated Holin (NP-Holin) Family". Transporter Classification Database. Retrieved 2016-03-28.

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