Neurite

A neurite refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete.[1]

Neurites are often packed with microtubule bundles, the growth of which is stimulated by neurotrophic factors, such as nerve growth factor (NGF), as well as tau proteins, MAP1 proteins, and MAP2.[2]

The neural cell adhesion molecule N-CAM simultaneously combines with another N-CAM and a fibroblast growth factor receptor to stimulate the tyrosine kinase activity of that receptor to induce the growth of neurites.[3]

There are several software kits available to facilitate neurite tracing in images (see external links).

Weak endogeneous electric fields may be used to both facilitate and direct the growth of projections from cell soma neurites, EFs of moderate strength have been used to direct and enhance neurite outgrowth in both murine and xenopus models. Co-culture of neurons with electrically aligned glial tissue also directs neurite outgrowth, as it is rich in neurotrophins that promote nerve growth .

See also

References

  1. ↑ Flynn, Kevin C (2013-01-01). "The cytoskeleton and neurite initiation". Bioarchitecture. 3 (4): 86–109. doi:10.4161/bioa.26259. ISSN 1949-0992. PMC 4201609Freely accessible.
  2. ↑ Bear, Mark F; Connors, Barry W.; Paradiso, Michael A., Neuroscience, Exploring the Brain, Philadelphia : Lippincott Williams & Wilkins; Third Edition (February 1, 2006). ISBN 0-7817-6003-8
  3. ↑ Berezin, Vladimir (2009-12-17). Structure and Function of the Neural Cell Adhesion Molecule NCAM. Springer Science & Business Media. ISBN 9781441911704.

External links


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