Nicholas A. Kotov

Nicholas A. Kotov

Nicholas A. Kotov
Born (1965-08-29) August 29, 1965
Moscow, USSR
Residence Ann Arbor, U.S.
Nationality American
Fields Chemistry, Chemical Engineering, Materials Science, Nanotechnology, Biomedical Engineering
Institutions University of Michigan
Alma mater Moscow State University
Known for self-assembling materials, layer-by-layer assembly, nanotechnology
Notable awards 2017 ACS Colloid Chemistry Award
2016 RSC Stephanie Kwolek Award[1]
2016 UNESCO Medal for Development of Nanoscience and Nanotechnologies[2]
2016 August T Larssons Visiting Scholar of the Swedish University of Agricultural Sciences
2014 Materials Research Society Medal (shared with Prof. Sharon Glotzer)[3]
Fellow of the Materials Research Society
Fellow of the Royal Society of Chemistry
Langmuir Lecturer Award of the American Chemical Society (2013)
The Charles M.A. Stine Award of the American Institute of Chemical Engineers[4]
Thomson Reuters Top 25 Materials Scientists of 2000-2010[5]
Thomson Reuters Top 100 Chemists of 2000-2010[6]
Wired Magazine’s Top 10 Discoveries of the Year (2007)[7]
NASA Nanotech Briefs Top 50 Award (2008)
Website
http://www.umkotov.com/

Nicholas A. Kotov, FRSC (born August 29, 1965, Moscow, USSR), is the Joseph B. and Florence V. Cejka Professor of Chemical Engineering at the University of Michigan in Ann Arbor, MI.[8] He is best known for his work on the self-assembly of nanoparticles[9] the layer-by-layer assembly (LbL)[10][11] of composites, and chiral nanostructures.[12]

The LbL deposition of charged macromolecular species was discovered in 1965 by J. J. Kirkland and R. K. Iler using films of microparticles,[13][14] and later re-discovered by Gero Decher in 1991 as a versatile deposition method for polyelectrolytes.[15] In his early work, Kotov extended this technique to nanoplatelets of clay, graphene, graphene oxide, and other nanoparticles, which provided a pathway towards the development of ultrastrong materials. Kotov found that these composites replicate the structure and mechanical properties of nacre,[16] which spurred on studies of nanoscale versions of nacre for application in neuroprosthetic devices, tissue engineering, and energy storage. His later studies led to the discovery of nanomaterials based on the Japanese art of kirigami,[17] and plasmonic nanocomposites.[18]

The biomimetic self-organization of nanoparticles is central to Kotov’s work. He discovered that inorganic nanoparticles can spontaneously self-organize into chains,[9] sheets,[19] nanowires, and particulate superlattices.[20] The geometry of these often sophisticated assemblies is determined by the fairly unsophisticated anisotropy of nanoparticle interactions. The diversity and complexity of nanoparticle assemblies approaches that of self-assembled structures of biomolecules,[21] and are rooted in the non-additivity of electrostatic, van der Waals and other classical interactions at the nanoscale.[22] Examples of the intricate self-organized assemblies achievable by nanoparticles include twisted ribbons[23] and virus-like nanohelices.[24]

Biomimicry of viruses in nanomaterials can also be seen in Kotov’s spherical supraparticles that are self-assembled from several hundred individual nanoparticles, replicating proteins in viral capsids.[25] The supraparticles can be related to micelles and vesicles, exemplifying terminal self-assembled structures. Their size and geometry is determined by the equilibrium state originating from the balance of repulsive and attractive interactions. The generic nature of such interactions allows the preparation of a large variety of supraparticles that may include different organic and inorganic components. The integration of nanoscale and biological components in supraparticles led to the first bionic nanoassemblies that integrated the functions of inorganic and biological components.[26]

The biomimetic functions of inorganic nanoparticles transitioned from laboratory to practice with Kotov’s discovery that pyramidal nanoparticles inhibit the essential bacterial enzyme β-galactosidase.[27] The capacity of these biomimetic nanoparticles to serve as new antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic resistant bacteria[28] addresses a pressing healthcare need.

Education and research career

Education and early career

Kotov received his MS (1987) and PhD (1990) degrees in chemistry from Moscow State University where his research concerned liquid-liquid interfaces imitating cell membranes for solar energy conversion. After graduation, he took up a postdoctoral position in the research group of Prof. Janos Fendler in the Department of Chemistry at Syracuse University.

Independent research career

Kotov took up a position as Assistant Professor of Chemistry at the Oklahoma State University in Stillwater, Oklahoma in 1996, gaining promotion to Associate Professor in 2001. In 2003 he moved to the University of Michigan where he is now the Joseph B. and Florence V. Cejka Professor of Chemical Engineering.

Professional achievements

Kotov serves as an Associate Editor for the journal ACS Nano,[29] and as an advisory board member of several other nanotechnology journals. He has received awards and recognitions from a number of different countries, international organizations, and multinational corporations. These include the 2017 Colloid Chemistry Award of the American Chemical Society, the 2016 Stephanie Kwolek Award of the Royal Society of Chemistry,[1] the 2016 UNESCO Medal for Development of Nanoscience and Nanotechnologies,[2] the 2014 MRS Medal,[3] the 2013 Langmuir Lecturer Award of the American Chemical Society,[30] and the 2012 Stine Award from the American Institute of Chemical Engineers.[4] He was also selected as a 2016 August T Larssons Visiting Scholar by the Swedish University of Agricultural Sciences (Sveriges Lantbruksuniversitet), a 2016 Fulbright Scholar, and as a Fellow of the Materials Research Society in 2014.[31] Kotov has also founded several start-up companies producing nanomaterials for transparent armor, energy storage, and biomedical applications. Together with his students Dr. Meghan Cuddihy and Dr. Jungwoo Lee, he used LbL coatings mimicking bone composites as a technical foundation for the commercialization of cell cultures in three-dimensional scaffolds as substrates for drug discovery.

Personal life

In 1991, Kotov married Elvira Stesikova, a PhD Chemist working on polymeric surfactants. They have two daughters, Sophia and Nicole.

References

  1. 1 2 "Kwolek Award". RSC. 2016-09-12. Retrieved 2016-09-12.
  2. 1 2 "UNESCO Award". UNESCO. 2016-09-12. Retrieved 2016-09-12.
  3. 1 2 "2014 MRS Medal". Materials Research Society. 2014-10-29. Retrieved 2014-10-29.
  4. 1 2 "Charles M.A. Stine Award". AIChE. 2013-02-15. Retrieved 2013-10-08.
  5. ↑ "Top 100 Materials Scientists | ScienceWatch | Thomson Reuters". ScienceWatch. Retrieved 2013-10-08.
  6. ↑ "Top 100 Chemists, 2000-2010 - ScienceWatch.com - Thomson Reuters". Archive.sciencewatch.com. Retrieved 2013-10-08.
  7. ↑ Rowe, Aaron. "Top 10 Scientific Breakthroughs of 2007". Wired.com. Retrieved 2013-10-08.
  8. ↑ "Nicholas A. Kotov | Michigan Engineering". Engin.umich.edu. Retrieved 2013-10-08.
  9. 1 2 Zhiyong Tang; Nicholas A. Kotov; Michael Giersig (2002). "Spontaneous Organization of Single CdTe Nanoparticles into Luminescent Nanowires". Science. 297: 237. Bibcode:2002Sci...297..237T. doi:10.1126/science.1072086.
  10. ↑ R. K. Iler (1966). "Multilayers of colloidal particles". Journal of Colloid and Interface Science. 21: 569. doi:10.1016/0095-8522(66)90018-3.
  11. ↑ G. Decher; J. D. Hong; J. Schmitt (1992). "Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces". Thin Solid Films. 210/211: 831. Bibcode:1992TSF...210..831D. doi:10.1016/0040-6090(92)90417-A.
  12. ↑ Wei Chen; Ai Bian; Ashish Agarwal; Liqiang Liu; Hebai Shen; Libing Wang; Chuanlai Xu; Nicholas A. Kotov (2009). "Nanoparticle Superstructures Made by Polymerase Chain Reaction: Collective Interactions of Nanoparticles and a New Principle for Chiral Materials". Nano Letters. 9: 2153–2159. doi:10.1021/nl900726s.
  13. ↑ J. J. Kirkland (1965). "Porous Thin-Layer Modified Glass Bead Supports for Gas Liquid Chromatography". Analytical Chemistry. 37: 1458. doi:10.1021/ac60231a004.
  14. ↑ R. K. Iler (1966). "Multilayers of colloidal particles". Journal of Colloid and Interface Science. 21: 569. doi:10.1016/0095-8522(66)90018-3.
  15. ↑ Gero Decher; Jong-Dal Hong (1991). "Buildup of ultrathin multilayer films by a self-assembly process, consecutive adsorption of anionic and cationic bipolar amphiphiles on charged surfaces". Macromolecular Symposia. 46: 321–327. doi:10.1002/masy.19910460145.
  16. ↑ Paul Podsiadlo; Amit K. Kaushik; Ellen M. Arruda; Anthony M. Waas; Bong Sup Shim; Jiadi Xu; Himabindu Nandivadu; Benjamin G. Pumplin; Joerg Lahann; Ayyalusamy Ramamoorthy; Nicholas A. Kotov (2007). "Ultrastrong and Stiff Layered Polymer Nanocomposites". Science. 318: 80. Bibcode:2007Sci...318...80P. doi:10.1126/science.1143176.
  17. ↑ Terry C. Shyu; Pablo F. Damasceno; Paul M. Dodd; Aaron Lamoureux; Lizhi Xu; Matthew Shlian; Sharon C. Glotzer; Nicholas A. Kotov (2015). "A kirigami approach to engineering elasticity in nanocomposites". Nature Materials. 14: 785–789. doi:10.1038/nmat4327.
  18. ↑ Yoonseob Kim; Bongjun Yeom; Oriol Arteaga; Seung Jo Yoo; Sang-Gil Lee; Jin-Gyu Kim; Nicholas A. Kotov (2016). "Reconfigurable chiroptical nanocomposites with chirality transfer from the macro- to the nanoscale". Nature Materials. 15: 461–468. doi:10.1038/nmat4525.
  19. ↑ Zhiyong Tang; Zhenli Zhang; Ying Wang; Sharon C. Glotzer; Nicholas A. Kotov (2006). "Self-Assembly of CdTe Nanocrystals into Free-Floating Sheets". Science. 314 (5797): 274–8. Bibcode:2006Sci...314..274T. doi:10.1126/science.1128045. PMID 17038616.
  20. ↑ N. A. Kotov; F. C. Meldrum; C. Wu; J. H. Fendler (1994). "Monoparticulate Layer and Langmuir-Blodgett-Type Multiparticulate Layers of Size-Quantized Cadmium Sulfide Clusters: A Colloid-Chemical Approach to Superlattice Construction". Journal of Physical Chemistry. 98: 2735. doi:10.1021/j100062a006.
  21. ↑ Nicholas A. Kotov (2010). "Inorganic Nanoparticles as Protein Mimics". Science. 330: 188. doi:10.1126/science.1190094.
  22. ↑ Carlos A. Silvera Batista; Ronald G. Larson; Nicholas A. Kotov (2015). "Non-Additivity of Nanoparticle Interactions". Science. 350: 1242477. doi:10.1126/science.1242477.
  23. ↑ Sudhanshu Srivastava; Aaron Santos; Kevin Critchley; Ki-Sub Kim; Paul Podsiadlo; Kai Sun; Jaebeom Lee; Chuanlai Xu; G. Daniel Lilly; Sharon C. Glotzer; Nicholas A. Kotov (2010). "Light-Controlled Self-Assembly of Semiconductor Nanoparticles into Twisted Ribbons". Science. 327: 1355. Bibcode:2010Sci...327.1355S. doi:10.1126/science.1177218.
  24. ↑ Yunlong Zhou; Ryan L. Marson; Greg van Anders; Jian Zhu; Guanxiang Ma; Peter Ercius; Kai Sun; Bongjun Yeom; Sharon Glotzer; Nicholas A. Kotov (2016). "Biomimetic Hierarchical Assembly of Helical Supraparticles from Chiral Nanoparticles". ACS Nano. 10: 3248–3256. doi:10.1021/acsnano.5b05983.
  25. ↑ Yunsheng Xia; Trung Dac Nguyen; Ming Yang; Byeongdu Lee; Aaron Santos; Paul Podsiadlo; Zhiyong Tang; Sharon C. Glotzer; Nicholas A. Kotov (2011). "Self-assembly of self-limiting monodisperse supraparticles from polydisperse nanoparticles". Nature Nanotechnology. 6: 580. Bibcode:2011NatNa...6..580X. doi:10.1038/nnano.2011.121.
  26. ↑ Jai Il Park; Trung Dac Nguyen; Gleiciani de Queirós Silveira; Joon Hwan Bahng; Sudhanshu Srivastava; Gongpu Zhao; Kai Sun; Peijun Zhang; Sharon C. Glotzer; Nicholas A. Kotov (2014). "Terminal Supraparticle Assemblies from Similarly Charged Protein Molecules and Nanoparticles". Nature Communications. 5: 3593. doi:10.1038/ncomms4593.
  27. ↑ Sang-Ho Cha; Jin Hong; Matt McGuffie; Bongjun Yeom; J. Scott VanEpps; Nicholas A. Kotov (2015). "Shape-Dependent Biomimetic Inhibition of Enzyme by Nanoparticles and Their Antibacterial Activity". ACS Nano. 9: 9097–9105. doi:10.1021/acsnano.5b03247.
  28. ↑ Matthew J. McGuffie; Jin Hong; Joong Hwan Bahng; Emmanouil Glynos; Peter F. Green; Nicholas A. Kotov; John G. Younger; J. Scott VanEpps (2016). "Zinc oxide nanoparticle suspensions and layer-by-layer coatings inhibit staphylococcal growth". Nanomedicine: Nanotechnology, Biology and Medicine. 12: 33–42. doi:10.1016/j.nano.2015.10.002.
  29. ↑ "ACS NANO : Editorial Board : Associate Editors". Pubs.acs.org. Retrieved 2013-10-08.
  30. ↑ "Langmuir Award". ACS. 2016-09-12. Retrieved 2016-09-12.
  31. ↑ "MRS Fellow". MRS. 2016-09-12. Retrieved 2016-09-12.
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