Nicotinamide mononucleotide

Nicotinamide mononucleotide

Names
IUPAC name 3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl]pyridinium
Other names Nicotinamide ribonucleoside 5'-phosphate Nicotinamide D-ribonucleotide β-Nicotinamide ribose monophosphate Nicotinamide nucleotide
Identifiers
CAS Number	1094-61-7
3D model (Jmol)	Interactive image
ChemSpider	13553
PubChem	16219737
InChI InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1 Key: DAYLJWODMCOQEW-TURQNECASA-N
SMILES c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
Properties
Chemical formula	C11H15N2O8P
Molar mass	334.22 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide. ^[1] Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.)^[2] As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.^[3]

Its precursor, niacin, is found in a variety of nutritional sources: peanuts, mushrooms (portobello, grilled), avocados, green peas (fresh), and certain fish and animal meats.^[4]

In studies on mice, NMN has shown to reverse age-related arterial dysfunction by decreasing oxidative stress.^[5] A long-term study indicates that NMN can slow down the physiologic decline in ageing mice.^[6] As a result, the older mice in the study have metabolism and energy levels resembling those of younger mice, with extended life spans. However, NMN did not show similar beneficial effects in young mice.^[7]

The anti-aging properties is being tested on humans in Japan.^{[8][9] [10]}

See also

• Nicotinamide riboside
• Niacin

References

1. Bieganowski P, Brenner C (2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans". Cell. 117: 495–502. doi:10.1016/s0092-8674(04)00416-7.
2. "niacinamide oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". Retrieved 2016-07-01.
3. Katrina L. Bogan; Charles Brenner. "Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition". Annual Review of Nutrition. 28: 115–130. doi:10.1146/annurev.nutr.28.061807.155443.
4. "Top 10 Foods Highest in Vitamin B3 (Niacin)". HealthAliciousNess. Retrieved 2016-07-01.
5. de Picciotto, Natalie E.; Gano, Lindsey B.; Johnson, Lawrence C.; Martens, Christopher R.; Sindler, Amy L.; Mills, Kathryn F.; Imai, Shin-ichiro; Seals, Douglas R. (2016-06-01). "Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice". Aging Cell. 15 (3): 522–530. doi:10.1111/acel.12461. ISSN 1474-9726. PMC 4854911. PMID 26970090.
6. Imai, Shin-ichiro (27 October 2016). "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice". Cell Metabolism: Online Now Articles. doi:10.1016/j.cmet.2016.09.013. Retrieved 28 October 2016.
7. "Scientists discover elixir of youth – for mice – and begin tests on humans". independent.co.uk. Independent (UK). Retrieved 28 October 2016.
8. http://the-japan-news.com/news/article/0003030620(subscriptionrequired)
9. "Scientists Are Close To Finding An Anti-Ageing Drug For Humans". 2016-07-12. Retrieved 2016-07-12.
10. "Scientists discover elixir of youth – for mice – and begin tests on humans". independent.co.uk. Independent (UK). Retrieved 28 October 2016.