Non-stop decay
Non-stop decay is a cellular mechanism of mRNA surveillance to detect mRNA molecules lacking a stop codon and prevent these mRNAs from translation. The non-stop decay pathway releases ribosomes that have reached the far 3' end of an mRNA and guides the mRNA to the exosome complex for selective degradation by RNase R in bacteria.[1][2] In contrast to NMD, polypeptides do not release from the ribosome, and thus, NSD seems to involve mRNA decay factors distinct from NMD.[3]
See also
- Nonsense-mediated decay, another mRNA surveillance mechanism
- mRNA surveillance
References
- ↑ Vasudevan; Peltz, SW; Wilusz, CJ; et al. (2002). "Non-stop decay--a new mRNA surveillance pathway". BioEssays. 24 (9): 785–8. doi:10.1002/bies.10153. PMID 12210514.
- ↑ Venkataraman, K; Guja, KE; Garcia-Diaz, M; Karzai, AW (2014). "Non-stop mRNA decay: a special attribute of trans-translation mediated ribosome rescue.". Frontiers in Microbiology. 5: 93. doi:10.3389/fmicb.2014.00093. PMC 3949413
. PMID 24653719. - ↑ Wu, X; Brewer, G (2012). "The regulation of mRNA stability in mammalian cells: 2.0.". Gene. 500: 10–21. doi:10.1016/j.gene.2012.03.021. PMC 3340483. PMID 22452843.
External links
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