Paul Knoepfler

Paul S. Knoepfler
Born (1967-04-10) April 10, 1967
Nationality United States of America
Fields Stem cells, Cancer Biology, Epigenomics
Notable awards Howard Temin Award
Website
www.chromatin.com

Paul S. Knoepfler (born April 10, 1967) is an American biologist, writer, and blogger. He is an associate professor in the Department of Cell Biology and Human Anatomy, the Genome Center, and the Comprehensive Cancer Center at the University of California, Davis School of Medicine.[1] In 2013 Knoepfler was named one of the 50 most influential people in the stem cell field[2] along with others such as Robert Lanza of Advanced Cell Technology as well as Nobel Laureates Shinya Yamanaka and John Gurdon.

Education

Knoepfler received a B.A. in English Literature from Reed College in 1989 and a Ph.D. in Molecular Pathology from the University of California, San Diego School of Medicine in 1998 as a Lucille P. Markey Fellow.[3]

Research

Knoepfler's research is focused on enhancing the safety of stem cell treatments including that of induced pluripotent stem cells[4][5] and developing novel therapies to target cancers, particularly brain tumors.[6] His lab studies the Myc oncogene and other factors that regulate stem and cancer cell chromatin including histone variant H3.3.[7]

Knoepfler did his postdoctoral studies at the Fred Hutchinson Cancer Research Center in the laboratory of Bob Eisenman, studying Myc regulation of chromatin in stem cells and cancers of the nervous system.[8] During his postdoctoral studies, Knoepfler received a fellowship from the Jane Coffin Childs Memorial Fund for Medical Research, and the Howard Temin Award from the National Cancer Institute (NCI).[9] The NCI award is named in honor of Dr. Howard Temin, who received the Nobel Prize in Physiology or Medicine in 1975 for his discoveries about RNA tumor viruses.

Knoepfler joined UC Davis in 2006 as an Assistant Professor, shortly after the formation of the California stem cell agency, the California Institute for Regenerative Medicine (CIRM).[10] His decision to move was influenced at least in part by the promise of CIRM to vitalize stem cell research in California.[11] He received a $2 million New Faculty Award from CIRM in 2008.[12] More recently he received the GPI national stem cell advocacy award in 2013.[13]

Knoepfler has also received support from the March of Dimes via the Basil O'Connor Starter Scholar Research Award[14] and from the National Brain Tumor Society.[15] Knoepfler was more recently awarded grants from the St. Baldrick's Foundation[16] to support work studying how Myc causes childhood brain cancers and potential ways to develop new treatments.[17][18]

Cancer, blogging and advocacy

Knoepfler was diagnosed with prostate cancer in late 2009 at age 42, an experience he credits at least in part as the inspiration to start blogging as an academic stem cell researcher.[19] At this time, Knoepfler is the only professor in United States and possibly the world who regularly blogs about stem cells.[20] Knoepfler remains in long-term remission from prostate cancer after surgery in 2009. In addition to blogging about stem cells, he openly blogged about his experience with prostate cancer,[21][22] a disease that is often not discussed openly by men.

Knoepfler received tenure in 2011 while actively blogging, an event he claims demonstrates a growing acceptance of social media in academia.[23] He is a proponent of scientific social media and has been listed as the top person to follow on Twitter to stay current on events in the stem cell field.[24] His blog at http://www.ipscell.com has broken a number of cutting edge stories in stem cell news in the last few years including the fraud of Hisashi Moriguchi of Japan who claimed to have transplanted iPS cells into humans as early as 2012,[25] the notable open third unawarded position for the 2012 Nobel Prize for Physiology or Medicine,[26] and the explosion of stem cell cosmetics.[27] In addition to his blogging, in 2013 Knoepfler released a book titled "Stem Cells: An Insider’s Guide",[28] which is aimed at a general audience of both scientists and non-scientists.[29]

As part of education and advocacy efforts, Knoepfler has supplied his own funds to support advancing the stem cell cause. In 2012, he awarded multiple $50 iTunes gift cards as prizes for a stem cell essay contest[30] and started a Stem Cell Person of the Year Award that includes a $1,000 cash prize given from Knoepfler's own money. The first winner of this award was stem cell and spinal cord injury patient advocate, Roman Reed.[31][32]

In 2015, Knoepfler has published a new book titled "GMO Sapiens: The Life-Changing Science of Designer Babies",[33] which discusses the science of human genetic modification. His second book covers the new CRISPR gene editing technology and its possible use in humans, cloning, eugenics, and transhumanism. Knoepfler advocates in the book for a temporary moratorium on clinical use of CRISPR in humans, whether for health condition or even human enhancement to create designer babies.[34] Watch TEDx Vienna video "What if my neighbor's kid was genetically modified?"[35] to find out more about his concerns on the use of CRISPR in humans.

References

  1. ↑ "http://www.ucdmc.ucdavis.edu/cellbio/faculty/knoepfler/". External link in |title= (help)
  2. ↑ "Top 50 most influential people on Stem Cells today" (PDF).
  3. ↑ "Faculty Profile".
  4. ↑ "Patient's own skin cells may treat diseases, UCD researcher says". Davis Enterprise.
  5. ↑ Vergano, Dan (May 20, 2009). "Controversy doesn't derail stem cell progress". USA Today.
  6. ↑ "St. Baldrick's Foundation awards $100,000 to UC Davis Scientist".
  7. ↑ "Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development". Epigenetics and Chromatin. doi:10.1186/1756-8935-6-7.
  8. ↑ "Myc in nervous-system development".
  9. ↑ "Paul Knoepfler receives five-year Howard Temin Award from the NCI".
  10. ↑ "Names of Stem Cell Researchers Moving to California Since Prop. 71".
  11. ↑ "California's stem cell agency ponders its future". USA Today. March 19, 2012.
  12. ↑ "UC Davis researcher gets $2M for stem cell research". Sacramento Business Journal.
  13. ↑ "Stem Cell Scientist Who Blogs To Receive Award For Advocacy". Forbes.
  14. ↑ "March of Dimes grant".
  15. ↑ "BTS Grant Recipients".
  16. ↑ "St. Baldrick's Grants".
  17. ↑ "$100,000 awarded to UC Davis stem cell researcher". Rocklin Today.
  18. ↑ "Name Droppers". Davis Enterprise.
  19. ↑ "My year as a stem-cell blogger". Nature News.
  20. ↑ "Like Touching Tomorrow: a Visit to the World Stem Cell Summit". Daily Kos.
  21. ↑ "My Cancer: how I became an advocate too".
  22. ↑ "Alumnus Profile: Stem Cell Blogger".
  23. ↑ "Alumnus Profile: Stem Cell Blogger".
  24. ↑ "Social media and stem cells: Time to start tweeting".
  25. ↑ "A not-so-Nobel story on cellular reprogramming". Nature News.
  26. ↑ Bardin, Jon (October 8, 2012). "Was anyone snubbed in Monday's Nobel Prize announcement?". LA Times.
  27. ↑ "In the Flesh: The Embedded Dangers of Untested Stem Cell Cosmetics". Scientific American.
  28. ↑ "UC Davis stem cell researcher warns consumers to beware of unproven or dangerous stem cell treatments". Sacramento Bee.
  29. ↑ "Stem Cells: An Insider's Guide – the new book by Paul Knoepfler".
  30. ↑ "$50 iTunes gift card for best stem cell essay". San Diego Union Tribute.
  31. ↑ "Stem cell person of year chosen". San Diego Union Tribune.
  32. ↑ "Roman Reed Foundation".
  33. ↑ http://www.worldscientific.com/worldscibooks/10.1142/9542
  34. ↑ http://www.amazon.com/Paul-Knoepfler/e/B00E91Q8LG/ref=dp_byline_cont_ebooks_1
  35. ↑ https://www.youtube.com/watch?v=y7LXwGfvxwo/ref=What if my neighbor's kid was genetically modified?
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