Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate

Names
Other names Phorbol dibutyrate; Phorbol 12,13-dibutanoate
Identifiers
CAS Number	37558-16-0
3D model (Jmol)	Interactive image
Abbreviations	PDBu
ChEBI	CHEBI:17598
ChemSpider	34645
ECHA InfoCard	100.164.231
KEGG	C03634
PubChem	37783
InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1 Key: BQJRUJTZSGYBEZ-YVQNUNKESA-N InChI=1/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1 Key: BQJRUJTZSGYBEZ-YVQNUNKEBT
SMILES CCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)CCC)O)C
Properties
Chemical formula	C28H40O8
Molar mass	504.62 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.^[1]

PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.

References

1. Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E (1983). "Phorbol ester receptors and the in vitro effects of tumor promoters". Annals of the New York Academy of Sciences. 407: 303–315. doi:10.1111/j.1749-6632.1983.tb47836.x. PMID 6309054.