Poorly differentiated thyroid cancer
| Poorly differentiated thyroid carcinoma | |
|---|---|
| Classification and external resources | |
| Specialty | oncology |
| ICD-10 | C73 |
| ICD-9-CM | 193 |
| eMedicine | med/ |
| MeSH | D013964 |
Poorly differentiated thyroid carcinoma (PDTC) is malignant neoplasm of follicular cell origin showing intermediate histopathological patterns between differentiated and undifferentiated thyroid cancers.[1]
Histopathological features
- Presence of small cells with round nuclei and scant cytoplasm with a diffuse solid pattern
- Round or oval nests (insulae) or in trabeculae.
- Solid growth and presence of microfollicles, some of which contain dense colloid.
- Extrathyroidal extension and blood vessel invasion
- Foci of necrosis,
- Larger than 5 cm in greatest diameter at diagnosis
Clinical features
References
- ↑ Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, Bussolati G, Rosai J (2007). "Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.". Am J Surg Pathol. 8 (31): 1256–64. doi:10.1097/PAS.0b013e3180309e6a. PMID 17667551.
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