Proflavine

Proflavine

Names
IUPAC name acridine-3,6-diamine
Identifiers
CAS Number	92-62-6
3D model (Jmol)	Interactive image
ChEBI	CHEBI:8452
ChEMBL	ChEMBL55400
ChemSpider	6832
DrugBank	DB01123
ECHA InfoCard	100.001.976
KEGG	C11181
PubChem	7099
UNII	CY3RNB3K4T
InChI InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 Key: WDVSHHCDHLJJJR-UHFFFAOYSA-N InChI=1/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2 Key: WDVSHHCDHLJJJR-UHFFFAOYAC
SMILES n1c3c(cc2c1cc(N)cc2)ccc(c3)N
Properties
Chemical formula	C13H11N3
Molar mass	209.25 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Proflavine (pron. pro-fla¢vin), also called proflavin and diaminoacridine and bate na bina, is an acriflavine derivative, a disinfectant bacteriostatic against many gram-positive bacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topical antiseptic, and was formerly used as a urinary antiseptic.

Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions.

Proflavine absorbs strongly in the blue region at 445 nm (in water at pH 7) with molar extinction coefficient of c. 40,000^[1]

References

1. Sarre, Peter J. (2006). "The Diffuse Interstellar Bands: A Major Problem in Astronomical Spectroscopy". arXiv:astro-ph/0608113.