PyBOP
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Names | |
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IUPAC name
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate | |
Other names
PyBOP | |
Identifiers | |
128625-52-5 ![]() | |
3D model (Jmol) | Interactive image |
ChemSpider | 2006820 ![]() |
ECHA InfoCard | 100.125.168 |
PubChem | 2724699 |
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Properties | |
C18H28F6N6OP2 | |
Molar mass | 520.40 g·mol−1 |
Appearance | White crystals |
Melting point | 150 °C (302 °F; 423 K) |
Hazards | |
Main hazards | Irritant |
R-phrases | R36/37/38 |
S-phrases | S26-S36 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent used in solid phase peptide synthesis. It is used as a substitute for the BOP reagent, thus avoiding the formation of the carcinogenic side product HMPA.[1]
See also
- BOP reagent
- DEPBT, a related reagent
- HATU
- HBTU
References
- ↑ Coste, J.; Le-Nguyen, D.; Castro, B. (1990). "PyBOP®: A new peptide coupling reagent devoid of toxic by-product". Tetrahedron Letters. 31 (2): 205. doi:10.1016/S0040-4039(00)94371-5.
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