REM Network

REM Network is an emerging concept that has been postulated by Matthias Werner Hentze, which tries to establish gene regulation by linking RNA, Enzymes and Metabolites.[1]

Emergence of REM Network Theory

The concept of REM Network is based on the fact that many housekeeping enzymes that are involved in metabolic pathways also bind to RNA molecules and regulate gene expression at translational levels. Glyceraldehyde-3-Phosphate Dehydrogenase[2] from glycolysis pathway, thymidylate synthesis cycle, serine hydroxymethyl-transferase and Dihydrofolate Reductase from thymidine synthesis pathway and cytosolic Aconitase have been widely studied.

References

  1. ↑ Hentze, Matthias; Thomas, Preiss (2010). "The REM phase of gene regulation". Trends in Biochemical Sciences. 35 (8): 423–6. doi:10.1016/j.tibs.2010.05.009. PMID 20554447.
  2. ↑ Dollenmaier, G; Weitz,, M (2003). "Interaction of glyceraldehyde-3- phosphate dehydrogenase with secondary and tertiary RNA structural elements of the hepatitis A virus 3' translated and non-translated regions". Journal of General Virology. 84 (2): 403–414. doi:10.1099/vir.0.18501-0.
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