Reissner's fiber

Reissner's fiber

Anatomical terminology

Reissner's fiber (named after Ernst Reißner) is a fibrous aggregation of secreted molecules extending from the subcommissural organ (SCO) through the ventricular system and central canal to the ampulla caudalis, a small ventricle-like structure at the end of the spinal cord.[1] In vertebrates, Reissner's fiber is formed by secretions of SCO-spondin from the subcommissural organ into the spinal fluid of the ventricular cavity.[2] Reissner's fiber is highly conserved, and present in the central canal of all chordates.[2] In cephalochordates, Reissner's fiber is produced by the ventral infundibular organ, as opposed to the dorsal SCO.[3]

Structure

Reissner’s fiber (RF) is a complex and dynamic structure present in the third and fourth ventricles and in the central canal of the spinal cord, observed in almost all vertebrates.[4][5]

It is formed by the assembly of complex and variable high weight molecular glycoproteins secreted by the SCO that are released to the cerebrospinal fluid. At least five different proteins were found, of 630 kDa, 480 kDa, 390 kDa, 320 kDa and, the major constituent, 200kDa that is present in both RF and cerebrospinal fluid, CSF. One of the most important RF-glycoproteins secreted by the SCO has been named SCO-spondin and is of major importance especially during embryonic life.[6][7]

Reissner’s fiber grows caudally by the addition of those glycoproteins at its cephalic end and extends along the brain aqueduct (Aqueduct of Sylvius), and the entire length of the central canal of the spinal cord, growing continuously in the caudal direction. It is just a small part of the secretions made by SCO and remains a matter of speculation, probably involved in many physiological functions as clearance of monoamines, detoxification of the CSF, neuronal surviving or the control of water balance.[6][8][9]

The glycoproteins forming RF can be found in three conformations, the first on is when the material aggregates over the SCO cilia, the so-called pre-RF, the second and most studied form known as the proper RF which is a cylindrical regular structure, and finally a third and final form, massa caudalis, known as the final distribution and the final assembly of the proteins.[9]

Development

This fiber is essentially made by glycoproteins, secreted by the subcommissural organ, of high molecular mass that are released into the cerebrospinal fluid. Here they aggregate on the top of the cilia, forming a thin film that becomes further packed in a highly ordered fashion to form threadlike supramolecular structure.[6]

The pre-RF material appears in the form of loosely arranged bundles of thin filaments. After this, it is plausible that some biochemical modifications may occur to the pre-RF material in order for it to condensate and form the exact Reissner’s fiber, such as disassembly and passage into neighboring vessels. Some of these changes may decrease the reactivity of the molecules, and this should be considered as a transitory stage, from pre to the proper RF, in which the accessibility of the antibodies to the epitopes is decreased. This lack of immunoreactivity could be due to the spatial distribution of sialic acid residues, with negative charge, within the fiber or might be the result of bound compounds interfering with the accessibility of the antibodies to RF- glycoproteins.[9]

The massa caudalis is the final form of this assembly of proteins, and is mostly related with the distal side of accumulation of the fiber and this final form have more filaments and is less compact than the middle form of the fiber.[6]

The secretory material is first synthesised at embryonic day3 (E3) by morphological undifferentiated neuroepithelial cells. At E7, post- coitum, the SCO-spondin it is released to embryonic CSF (ECSF), however RF does not form until E11 and only at E12 the RF is present in the lumbar spinal cord. The mechanisms that trigger RF formation remain unknown, but probably factors other that ventricular released must be required for the formation of the fiber, like the hydrodynamics of the CSF.[8]

Function

SCO-RF complex

This complex may participate in the maintenance of water and electrolyte homeostasis (osmoregulation), during ontogeny and in the composition of the cerebrospinal fluid.[8][9]

The SCO-RF has been linked to various and different aspects of water and electrolyte metabolism and it is proven that water deprivation enhances the secretory activity of the SCO. This helps prove the correction between this complex and the adrenal cortex and it has been reported the presence in the SCO-RF of receptors or binding sites for peptides involved in hydromineral balance such as angiotensin II. This complex is involved in many physiological functions like development of spinal cord, the pathophysiology of lordosis or the neuronal survival in a more developmental pathway.[10][11]

RF and the cerebrospinal fluid

Reissner’s fiber, because of the sialic acid residues with negative charge, might participate in the cleaning of the CSF. The glycoproteins bind biogenic amines present in the CSF like dopamine, serotonin or noradrenaline controlling this way the concentration of these monoamines by ionic change. There are, however, differences in the biding characteristics of each of these amines; the binding of serotonin is more unstable, and it occurs only when its CSF concentration is high, but on the other hand, noradrenaline binds strongly to the RF and remains bound as it moves along the central canal in the same binding site of adrenaline.[10][12]

The concentration of these monoamines in the CSF in Reissner’s fiber deprived animals was investigated, and it was possible to conclude that this fiber is involved in the cleaning of the liquid because those animals display as increased in the CSF concentration of several amines, being L-DOPA the one with the highest rise. All findings obtained indicate that RF binds monoamines present in the ventricular CSF and then transports them along the central canal. In the absence of RF, the CSF concentration of monoamines increased sharply.[13]

References

  1. ↑ Butler, Ann; William Hodos (Aug 23, 2005). Comparative Vertebrate Neuroanatomy: Evolution and Adaptation. John Wiley & Sons,. p. 715. ISBN 0471888893.
  2. 1 2 Gobron, S.; Creveaux, I.; Meiniel, R.; Didier, R.; Dastugue, B.; Meiniel, A. (1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–664. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783.
  3. ↑ Vigh, B. L.; Vigh-Teichmann, I. (1998). "Actual problems of the cerebrospinal fluid-contacting neurons". Microscopy Research and Technique. 41 (1): 57–83. doi:10.1002/(SICI)1097-0029(19980401)41:1<57::AID-JEMT6>3.0.CO;2-R. PMID 9550137.
  4. ↑ Hofer H, Meinel W, Erhardt H (1980). "Electron microscopic study of the origin and formation of Reissner's fiber in the subcommissural organ of Cebus apella (Primates, Platyrrhini)". Cell and Tissue Research. 205 (2): 295–301. doi:10.1007/bf00234687. PMID 6766807.
  5. ↑ Castañeyra-Perdomo A, Meyer G, Ferres-Torres R (1983). "Development of the subcommissural organ in the albino mouse (a Golgi study)". Journal Für Hirnforschung. 24 (4): 363–70. PMID 6643990.
  6. 1 2 3 4 Oksche A, Rodríguez EM, Llebrez PF (1993). The Subcommissural Organ: An Ependymal Brain Gland. Berlin: Springer Verlag. ISBN 978-3-540-56336-5. OCLC 27681500.
  7. ↑ Rodríguez EM, Oksche A, Montecinos H (March 2001). "Human subcommissural organ, with particular emphasis on its secretory activity during the fetal life". Microscopy Research and Technique. 52 (5): 573–90. doi:10.1002/1097-0029(20010301)52:5<573::AID-JEMT1042>3.0.CO;2-6. PMID 11241867.
  8. 1 2 3 Chatoui H, El Hiba O, Elgot A, Gamrani H (April 2012). "The rat SCO responsiveness to prolonged water deprivation: implication of Reissner's fiber and serotonin system". Comptes Rendus Biologies. 335 (4): 253–60. doi:10.1016/j.crvi.2012.03.011. PMID 22578571.
  9. 1 2 3 4 Meiniel R, Meiniel A (1985). "Analysis of the secretions of the subcommissural organs of several vertebrate species by use of fluorescent lectins". Cell and Tissue Research. 239 (2): 359–64. doi:10.1007/bf00218016. PMID 3919951.
  10. 1 2 Pérez-Fígares JM, Jimenez AJ, Rodríguez EM (March 2001). "Subcommissural organ, cerebrospinal fluid circulation, and hydrocephalus". Microscopy Research and Technique. 52 (5): 591–607. doi:10.1002/1097-0029(20010301)52:5<591::AID-JEMT1043>3.0.CO;2-7. PMID 11241868.
  11. ↑ Elgot A, Ahboucha S, Bouyatas MM, Fèvre-Montange M, Gamrani H (November 2009). "Water deprivation affects serotoninergic system and glycoprotein secretion in the sub-commissural organ of a desert rodent Meriones shawi". Neuroscience Letters. 466 (1): 6–10. doi:10.1016/j.neulet.2009.08.058. PMID 19716402.
  12. ↑ Caprile T, Hein S, Rodríguez S, Montecinos H, Rodríguez E (February 2003). "Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid". Brain Research. Molecular Brain Research. 110 (2): 177–92. doi:10.1016/S0169-328X(02)00565-X. PMID 12591155.
  13. ↑ Hoyo-Becerra C, López-Avalos MD, Pérez J, et al. (December 2006). "Continuous delivery of a monoclonal antibody against Reissner's fiber into CSF reveals CSF-soluble material immunorelated to the subcommissural organ in early chick embryos". Cell and Tissue Research. 326 (3): 771–86. doi:10.1007/s00441-006-0231-3. PMID 16788834.
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