Sandra Saouaf
| Sandra Saouaf | |
|---|---|
 Chemical Heritage Foundation, Philadelphia, PA, 2011 | |
| Nationality | American |
| Other names | Sandra Jerrold-Jones, Sandra J. Saouaf |
| Alma mater |
Rutgers College University of Pennsylvania |
| Occupation | immunologist |
| Years active | 1995-present |
| Employer |
Bristol-Myers Squibb GlaxoSmithKline University of Pennsylvania Atlantic Bio Sci, LLC |
Sandra Saouaf is an American immunologist who researches autoimmune diseases, such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis and others.
Biography
Sandra Jerrold-Jones obtained a BA from Rutgers College in biology and went on to earn a PhD in Immunology from the University of Pennsylvania.[1] After completion of her degree, Saouaf went to work in the molecular biology laboratory of Bristol-Myers Squibb[2][3] where she completed her post doctorate fellowship.[4] She then worked briefly at GlaxoSmithKline before returning to the University of Pennsylvania.[2] In 2007, after a discovery that the FOXP3 protein produced results that it could play a role in making regulatory immune cells more stable, she began working on a mouse model to extend the work.[5] Saouaf left the university and began a consulting business with pharmaceutical and biotechnical companies,[2] hoping to help speed the process of discoveries for drugs to treat autoimmune disease. In 2012, she "discovered a possible treatment approach...through oral drugs" and founded Atlantic Bio Sci, LLC.[1] In 2013, she won a Fellowship from the Alliance of Women Entrepreneurs.[6]
Selected works
- Weiner, D B; Williams, W V; Siegel, R M; Jerrold-Jones, S, et. al. (January 1989). "Molecular characterization of suppressor T cells". Transplantation Proceedings. 20 (6): 1151–1153.
- Siegel, Richard M; Katsumata, Makoto; Komori, Shinji; Jerrold-Jones, Sandra, et. al. (December 1990). "Mechanisms of Autoimmunity in the Context of T-Cell Tolerance: Insights from Natural and Transgenic Animal Model Systems". Immunological Reviews. 118 (1): 165–192. doi:10.1111/j.1600-065X.1990.tb00816.x.
- Saouaf, Sandra J; Mahajan, Sandeep; Rowley, R Bruce; Kut, Stephanie A, et. al. (September 1994). "Temporal Differences in the Activation of Three Classes of Non-Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement". Proceedings of the National Academy of Sciences of the United States of America. 91 (20): 9524–9528.
- Saouaf, Sandra J; Kut, Stephanie A; Fargnoli, Joseph; Rowley, R Bruce, et. al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". The Journal of biological chemistry. Baltimore, Maryland: American Society for Biochemistry and Molecular Biology. 270 (45): 27072.
- Saouaf, Sandra J; Brennan, Patrick J; Shen, Yuan; Greene, Mark I. (December 2003). "Mechanisms of peripheral immune tolerance: Conversion of the immune to the unresponsive phenotype". Immunologic Research. 28 (3): 193–199.
- Iacono, Kathryn T.; Brown, Amy L.; Greene, Mark I.; Saouaf, Sandra J. (December 2007). "CD147 Immunoglobulin Superfamily Receptor Function and Role in Pathology". Experimental and Molecular Pathology. 83 (3): 283–295. doi:10.1016/j.yexmp.2007.08.014.
- Saouaf, Sandra J; Brennan, Patrick J; Shen, Yuan; Greene, Mark I. (October 2009). "Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis". Experimental and Molecular Pathology. 87 (2): 99–104.
References
- 1 2 Friedman, Sally (8 July 2014). "Moorestown doctor on crusade against common disorders". Courier Post. Retrieved 25 November 2015.
- 1 2 3 "Women in STEM: Professional Advice for High School Students". Aston, Pennsylvania: Neumann University. 24 October 2014. Retrieved 25 November 2015.
- ↑ Gupta, et. al 2013, p. 131.
- ↑ "Sandra Saouaf". Connect6. Retrieved 25 November 2015.
- ↑ "Researchers discover new molecular path to fight autoimmune diseases". Phys.org. 6 March 2007. Retrieved 25 November 2015.
- ↑ "Meet Our 2013 Fellows". Pottstown, Pennsylvania: Alliance of Women Entrepreneurs. 2013. Retrieved 25 November 2015.
Bibliography
- Gupta, Sudhir; Paul, William E.; DeFranco, Anthony; Perlmutter, Roger (2013). Mechanisms of Lymphocyte Activation and Immune Regulation V: Molecular Basis of Signal Transduction. New York: Springer Science & Business Media. ISBN 978-1-4899-0987-9.