Wild-type transthyretin amyloid

Wild-type transthyretin amyloid (WTTA), also known as senile systemic amyloidosis (SSA),[1] is a disease that typically affects the heart and tendons of elderly people. It is caused by accumulation of a wild-type (that is to say a normal) protein called transthyretin. This is in contrast to a related condition called transthyretin-related hereditary amyloidosis where a genetically mutated transthyretin protein tends to deposit at a much earlier age than in WTTA, due to abnormal conformation and bioprocessing. It belongs to a group of diseases called amyloidosis, chronic progressive conditions linked to abnormal deposition of normal or abnormal proteins, because these proteins are misshapen and cannot be properly degraded and eliminated by the cell metabolism.

Natural Course of the Disease

The disorder typically affects the heart and its prevalence increases in older age groups. Men are affected much more frequently then women.[2] In fact, up to 25% of men over the age of 80 may have evidence of WTTA.[3]

Patients often present with increased thickness of the wall of the main heart chamber, the left ventricle. People affected by WTT amyloidosis are likely to have required a pacemaker before diagnosis and have a high incidence of a partial electrical blockage of the heart, known as left bundle branch block. Low ECG signals such as QRS complexes are widely considered a marker of cardiac amyloidosis.[4]

A much better survival has been reported for patients with WTTA as opposed to cardiac AL amyloidosis .[5]

Signs and Symptoms

Wild-Type Transthyretin Amyloid accumulates mainly in the heart, where it causes stiffness and often thickening of its walls, leading consequently to shortness of breath and intolerance to exercise, called diastolic dysfunction. Excessively slow heart rate can also occur, such as in sick sinus syndrome, with ensuing fatigue and dizziness. Wild-type transthyretin deposition is also a common cause of carpal tunnel syndrome in elderly men, which may cause pain, tingling and loss of sensation in the hands. Some patients may develop carpal tunnel syndrome as an initial symptom of Wild-Type Transthyretin Amyloid.[6] There appears to be an increase in the risk for developing hematuria or blood in the urine due to urological lesions.

Diagnosis

The condition is suspected in an elderly person, especially male, presenting with symptoms of heart failure such as shortness of breath or swollen legs, and or disease of the electrical system of the heart with ensuing slow heart rate, dizziness or fainting spells.[7] The diagnosis is confirmed on the basis of a biopsy, which can be treated with a special stain called Congo Red that will be positive in this condition, and immunohistochemistry.

Treatment

No specific drug has been clearly shown to be able to arrest or slow down the process of this condition [8] There is promise that two drugs, tafamidis and diflunisal,[9] may improve the outlook, since they were demonstrated in randomized clinical trials to benefit patient affected by the related condition FAP-1 otherwise known as Transthyretin-related hereditary amyloidosis. Permanent pacing can be employed in cases of symptomatic slow heart rate ( bradycardia ). Heart failure medications can be used to treat symptoms of difficulty breathing and congestion. [10]

See also

External links

References

  1. ↑ Pinney, Jennifer H.; Whelan, Carol J.; Petrie, Aviva; Dungu, Jason; Banypersad, Sanjay M.; Sattianayagam, Prayman; Wechalekar, Ashutosh; Gibbs, Simon D. J.; Venner, Christopher P. (2013-04-24). "Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome". Journal of the American Heart Association. 2 (2): e000098. doi:10.1161/JAHA.113.000098. ISSN 2047-9980. PMC 3647259Freely accessible. PMID 23608605.
  2. ↑ "Senile systemic amyloidosis presenting with heart failure: A comparison with light chain–associated amyloidosis". Archives of Internal Medicine. 165 (12): 1425–1429. 2005-06-27. doi:10.1001/archinte.165.12.1425. ISSN 0003-9926.
  3. ↑ Tanskanen, Maarit; Peuralinna, Terhi; Polvikoski, Tuomo; Notkola, Irma‐Leena; Sulkava, Raimo; Hardy, John; Singleton, Andrew; Kiuru‐Enari, Sari; Paetau, Anders (2008-01-01). "Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2‐macroglobulin and tau: A population‐based autopsy study". Annals of Medicine. 40 (3): 232–239. doi:10.1080/07853890701842988. ISSN 0785-3890.
  4. ↑ Falk, Rodney H. (2005-09-27). "Diagnosis and Management of the Cardiac Amyloidoses". Circulation. 112 (13): 2047–2060. doi:10.1161/CIRCULATIONAHA.104.489187. ISSN 0009-7322. PMID 16186440.
  5. ↑ Rapezzi, Claudio; Merlini, Giampaolo; Quarta, Candida C.; Riva, Letizia; Longhi, Simone; Leone, Ornella; Salvi, Fabrizio; Ciliberti, Paolo; Pastorelli, Francesca (2009-09-29). "Systemic Cardiac Amyloidoses Disease Profiles and Clinical Courses of the 3 Main Types". Circulation. 120 (13): 1203–1212. doi:10.1161/CIRCULATIONAHA.108.843334. ISSN 0009-7322. PMID 19752327.
  6. ↑ Sekijima, Yoshiki; Uchiyama, Shigeharu; Tojo, Kana; Sano, Kenji; Shimizu, Yusaku; Imaeda, Toshihiko; Hoshii, Yoshibonu; Kato, Hiroyuki; Ikeda, Shu-ichi (2011-01-01). "High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly". Human Pathology. 42 (11): 1785–91. doi:10.1016/j.humpath.2011.03.004. PMID 21733562.
  7. ↑ Banypersad SM, Moon JC, Whelan C. Contemporary Reviews. Updates in Cardiac Amyloidosis: A Review. J Am Heart Assoc. 2012; 1: e000364
  8. ↑ Sekijima Y. Postgrad Med J. 2015 Jun 5. pii: postgradmedj-2014-133224. doi: 10.1136/postgradmedj-2014-133224. The transthyretin amyloidoses: advances in therapy. Dubrey S, Ackermann E, Gillmore J.
  9. ↑ Sekijima Y. Recent progress in the understanding and treatment of transthyretin amyloidosis. J Clin Pharm Ther. 2014 Jun;39(3):225-33. doi: 10.1111/jcpt.12145.
  10. ↑ CC Quarta, JL Kruger, RH Faulk; Cardiac Amyloidosis. Circulation 2012 June;126 ( 12 ) http://dx.doi.org/10.1161/CIRCULATIONAHA.111.069195
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