Stigmastanol

Stigmastanol

Names
IUPAC name (3S,5S,8R,9S,10S,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
Other names (3β)-Stigmastan-3-ol; (3β,5α)-Stigmastan-3-ol; β-Sitostanol; Dihydrositosterin; Dihydrositosterol; Dihydro-β-sitosterol; Fucostanol; Spinastanol; 24α-Ethylcholestanol
Identifiers
CAS Number	83-45-4
3D model (Jmol)	Interactive image
ChEBI	CHEBI:89400
ChEMBL	ChEMBL252364
ChemSpider	13078158
ECHA InfoCard	100.001.345
PubChem	15559396
UNII	C2NJ9WO6O7
SMILES O[C@H]1CC[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CC[C@@H](CC)C(C)C)C)([H])C1
Properties
Chemical formula	C29H52O
Molar mass	416.73 g·mol^−1
Boiling point	139.4 to 139.8 °C (282.9 to 283.6 °F; 412.5 to 412.9 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Stigmastanol (sitostanol) is a phytosterol found in a variety of plant sources. Similar to sterol esters and stanol esters, stigmastanol inhibits the absorption of cholesterol from the diet.^[2][3][4] Animal studies suggest that it also inhibits biosynthesis of cholesterol in the liver.^[2]

Stigmastanol is the product of the reduction of β-sitosterol^[5] and the hydrogenation of stigmasterol.^[6]

See also

• Stigmasterol, a closely related sterol

References

1. Sandqvist, Hakan; Bengtsson, Edvard (1931). "The empirical formula of sitosterol". Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen. 64B: 2167–2171.
2. Batta, Ashok K.; Xu, Guorong; Honda, Akira; Miyazaki, Teruo; Salen, Gerald (2006). "Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat". Metabolism, Clinical and Experimental. 55 (3): 292–299. doi:10.1016/j.metabol.2005.08.024.
3. Heinemann T, Pietruck B, Kullak-Ublick G, von Bergmann K (1988). "Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption". Agents and actions. Supplements. 26: 117–122. PMID 3265272.
4. Heinemann T, Kullak-Ublick GA, Pietruck B, von Bergmann K (1991). "Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol". European journal of clinical pharmacology. 40 (Suppl 1): S59–63. doi:10.1007/BF01409411. PMID 2044646.
5. Thomasson Crompton, David William; Nickol, Brent B. (1985). Biology of the Acanthocephala. Cambridge University Press. p. 185. ISBN 9780521246743.
6. Paxena, P. B. (2007). Chemistry of Alkaloids. Discovery Publishing Hous. p. 231. ISBN 9788183563161.