TAPI-1
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Names | |
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Systematic IUPAC name
N-{(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-(2-naphthyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide | |
Identifiers | |
163847-77-6 | |
3D model (Jmol) | Interactive image |
ChemSpider | 8634035 |
PubChem | 10458621 |
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Properties | |
C26H37N5O5 | |
Molar mass | 499.61 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
TAPI-1 ( TNF-alpha protease inhibitor I) is a structural analog of TAPI-0 with similar but more stable validness in vitro for the matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme[1] which blocks shedding of several cell surface proteins such as IL-6 and p60 TNF receptor.[2]
References
- ↑ Müllberg J rt al; Durie; Otten-Evans; Alderson; Rose-John; Cosman; Black; Mohler (Dec 1, 1995). "A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor". J Immunol. 155 (11): 5198–5205. PMID 7594530.
- ↑ "TAPI-1 biological activity". selleckchemicals.
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