TcdE holin family

The Clostridium difficile TcdE Holin (TcdE Holin) Family (TC# 1.E.19) is a group of transporters belonging to the Holin Superfamily IV.[1] A representative list of its members can be found in the Transporter Classification Database.

Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 amino acyl (aa) protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis. Other Clostridial species bear homologues of TcdE.[2][3]

The transport reaction believed to be catalyzed by TcdE is:

Toxin (in) → Toxin (out)

See also

Further reading

References

  1. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059Freely accessible. PMID 23856191.
  2. Spigaglia, Patrizia; Mastrantonio, Paola (2002-09-01). "Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates". Journal of Clinical Microbiology. 40 (9): 3470–3475. doi:10.1128/jcm.40.9.3470-3475.2002. ISSN 0095-1137. PMC 130716Freely accessible. PMID 12202595.
  3. Cohen, S. H.; Tang, Y. J.; Silva, J. (2000-02-01). "Analysis of the pathogenicity locus in Clostridium difficile strains". The Journal of Infectious Diseases. 181 (2): 659–663. doi:10.1086/315248. ISSN 0022-1899. PMID 10669352.

As of this edit, this article uses content from "1.E.19 The Clostridium difficile TcdE Holin (TcdE Holin) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.


This article is issued from Wikipedia - version of the 11/8/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.