Thyroglobulin domain
Thyroglobulin type-1 repeat | |||||||||
---|---|---|---|---|---|---|---|---|---|
Thyroglobulin type-1 domain | |||||||||
Identifiers | |||||||||
Symbol | Thyroglobulin_1 | ||||||||
Pfam | PF00086 | ||||||||
InterPro | IPR000716 | ||||||||
PROSITE | PDOC00377 | ||||||||
SCOP | 1icf | ||||||||
SUPERFAMILY | 1icf | ||||||||
CDD | cd00191 | ||||||||
|
Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.
Human proteins containing this domain
CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1; TACSTD2; TG;
References
- Gunčar, G.; Pungerčič, G.; Klemenčič, I.; Turk, V.; Turk, D. A. (1999). "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S". The EMBO Journal. 18 (4): 793–803. doi:10.1093/emboj/18.4.793. PMC 1171172
. PMID 10022822.
- Molina, F.; Bouanani, M.; Pau, B.; Granier, C. (1996). "Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families". European Journal of Biochemistry / FEBS. 240 (1): 125–133. doi:10.1111/j.1432-1033.1996.0125h.x. PMID 8797845.
This article incorporates text from the public domain Pfam and InterPro IPR000519
This article is issued from Wikipedia - version of the 2/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.