Tombusvirus internal replication element (IRE)

Tombusvirus internal replication element (IRE)

Predicted secondary structure and sequence conservation of Tombus_IRE
Identifiers
Symbol Tombus_IRE
Rfam RF00510
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

In virology, the tombusvirus internal replication element (IRE) is a segment of RNA located within the region coding for p92 polymerase. This element is essential for viral replication; specifically, it is thought to be required at an early stage of replication, such as template recruitment and/or replicase complex assembly.[1]

Other non-coding RNA structures in Tombusvirus include the 3' UTR region IV[2] and 5' UTR.[3][4]

References

  1. Monkewich, S; Lin HX; Fabian MR; Xu W; Na H; Ray D; Chernysheva OA; Nagy PD; White KA (2005). "The p92 Polymerase Coding Region Contains an Internal RNA Element Required at an Early Step in Tombusvirus Genome Replication". J Virol. 79 (8): 48484858. doi:10.1128/JVI.79.8.4848-4858.2005. PMC 1069561Freely accessible. PMID 15795270.
  2. Fabian MR, Na H, Ray D, White KA (2003). "3'-Terminal RNA secondary structures are important for accumulation of tomato bushy stunt virus DI RNAs". Virology. 313 (2): 567–80. doi:10.1016/S0042-6822(03)00349-0. PMID 12954222.
  3. Wu B, Vanti WB, White KA (2001). "An RNA domain within the 5' untranslated region of the tomato bushy stunt virus genome modulates viral RNA replication". J. Mol. Biol. 305 (4): 741–56. doi:10.1006/jmbi.2000.4298. PMID 11162089.
  4. Ray D, Na H, White KA (2004). "Structural properties of a multifunctional T-shaped RNA domain that mediate efficient tomato bushy stunt virus RNA replication". J. Virol. 78 (19): 10490–500. doi:10.1128/JVI.78.19.10490-10500.2004. PMC 516415Freely accessible. PMID 15367615.


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