William Spence (disambiguation)
William Spence was an Australian politician.
William Spence may also refer to:
- William Spence (entomologist) (c. 1783–1860), British economist and entomologist
- William Spence (mathematician) (1777–1815), Scottish mathematician
- Billy Spence (died 1980), loyalist activist in Northern Ireland
- William Spence (MP), MP for Sussex
- William Blundell Spence (1814–1900), English artist and art dealer
- William Robert Spence (1875-1954), Scottish trade union leader
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