Zona pellucida-like domain

Zona pellucida-like domain
Identifiers
Symbol	Zona_pellucida
Pfam	PF00100
InterPro	IPR001507
SMART	SM00241
PROSITE	PDOC00577
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Zona pellucida-like domain (ZP domain / ZP-like domain) is a family of evolutionarily related proteins.^[1][2]

A large domain, containing around 260 amino acids, has been recognised in a variety of receptor-like eukaryotic glycoproteins.^[1] All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region, often followed by either a transmembrane region and a very short cytoplasmic region or by a GPI-anchor. The domain common to all these proteins is a bipartite protein polymerization module ^[3][4] that is located in the C-terminal portion of the extracellular region and contains 8 or 10 conserved Cys residues involved in disulfide bonds.^[5][6]

Examples

Humans genes encoding proteins containing this domain include:

• CUZD1
• DMBT1
• ENG
• GP2
• OIT3
• POMZP3
• TECTA, TECTB, TGFBR3
• UMOD, UMODL1
• ZP1, ZP2, ZP3, ZP4, ZPLD1

References

1. Bork P, Sander C (April 1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. doi:10.1016/0014-5793(92)80853-9. PMID 1313375.
2. Jovine L, Darie CC, Litscher ES, Wassarman PM (2005). "Zona pellucida domain proteins". Annu. Rev. Biochem. 74: 83–114. doi:10.1146/annurev.biochem.74.082803.133039. PMID 15952882.
3. Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM (2002). "The ZP domain is a conserved module for polymerization of extracellular proteins". Nat Cell Biol. 4 (6): 457–61. doi:10.1038/ncb802. PMID 12021773.
4. Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A duplicated motif controls assembly of zona pellucida domain proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 5922–7. doi:10.1073/pnas.0401600101. PMC 395899. PMID 15079052.
5. Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. doi:10.1038/nature07599. PMID 19052627. PDB: 3D4C​ PDB: 3D4G​ PDB: 3EF7​
6. Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3​ PDB: 3NK4​

This article incorporates text from the public domain Pfam and InterPro IPR001507