ACER3

ACER3
Identifiers
Aliases	ACER3, APHC, PHCA, alkaline ceramidase 3
External IDs	MGI: 1913440 HomoloGene: 5410 GeneCards: ACER3
Gene ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides • hydrolase activity • phytoceramidase activity Cellular component • integral component of membrane • integral component of Golgi membrane • integral component of endoplasmic reticulum membrane • Golgi membrane • Golgi apparatus • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • sphingosine biosynthetic process • sphingolipid biosynthetic process • phytosphingosine biosynthetic process • ceramide metabolic process • positive regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55331	66190
Ensembl	ENSG00000078124	ENSMUSG00000030760
UniProt	Q9NUN7	Q9D099
RefSeq (mRNA)	NM_001300953 NM_001300954 NM_001300955 NM_018367	NM_025408
RefSeq (protein)	NP_060837.3	NP_079684.2
Location (UCSC)	Chr 11: 76.86 – 77.03 Mb	Chr 7: 98.21 – 98.32 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846.
4. Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

External links

• Human ACER3 genome location and ACER3 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G, ed. "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.". PLoS Genet. 5 (10): e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811. PMID 19834535.