ACIN1

ACIN1
Identifiers
Aliases	ACIN1, ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1
External IDs	MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1
Gene ontology Molecular function • nucleotide binding • ATPase activity • protein binding • RNA binding • enzyme binding • poly(A) RNA binding • nucleic acid binding Cellular component • cytoplasm • cytosol • nuclear speck • plasma membrane • exon-exon junction complex • nucleoplasm • nucleolus • ASAP complex • nucleus Biological process • cellular component disassembly involved in execution phase of apoptosis • apoptotic chromosome condensation • mRNA processing • negative regulation of mRNA splicing, via spliceosome • RNA splicing • positive regulation of apoptotic process • positive regulation of monocyte differentiation • erythrocyte differentiation • xenophagy • positive regulation of defense response to virus by host • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22985	56215
Ensembl	ENSG00000100813	ENSMUSG00000022185
UniProt	Q9UKV3	Q9JIX8
RefSeq (mRNA)	NM_001164814 NM_001164815 NM_001164816 NM_001164817 NM_014977	NM_001085472 NM_001085473 NM_001242605 NM_001242606 NM_019567 NM_023190
RefSeq (protein)	NP_001158286.1 NP_001158287.1 NP_001158288.1 NP_001158289.1 NP_055792.1	NP_001078942.2 NP_001229534.1 NP_062513.3 NP_075679.2
Location (UCSC)	Chr 14: 23.06 – 23.1 Mb	Chr 14: 54.64 – 54.69 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
4. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. doi:10.1038/43678. PMID 10490026.
5. "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

External links

• Human ACIN1 genome location and ACIN1 gene details page in the UCSC Genome Browser.

Further reading

• Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation.". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
• Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages.". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
• Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis.". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma.". Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.