ALG13

ALG13
Identifiers
Aliases	ALG13, CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W, EIEE36, UDP-N-acetylglucosaminyltransferase subunit
External IDs	HomoloGene: 78772 GeneCards: ALG13
Gene ontology Molecular function • thiol-dependent ubiquitinyl hydrolase activity • transferase activity • poly(A) RNA binding • peptidase activity • cysteine-type peptidase activity • transferase activity, transferring hexosyl groups • protein binding • catalytic activity • hydrolase activity • transferase activity, transferring glycosyl groups • N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Cellular component • endoplasmic reticulum membrane • endoplasmic reticulum Biological process • dolichol-linked oligosaccharide biosynthetic process • metabolic process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79868	n/a
Ensembl	ENSG00000101901	n/a
UniProt	Q9NP73	n/a
RefSeq (mRNA)	NM_001039210 NM_001099922 NM_001168385 NM_001257230 NM_001257231 NM_001257234 NM_001257235 NM_001257237 NM_001257239 NM_001257240 NM_001257241 NM_018466 NM_001324290 NM_001324291 NM_001324292 NM_001324293 NM_001324294	n/a
RefSeq (protein)	NP_001034299.3 NP_001093392.1 NP_001161857.1 NP_001244159.1 NP_001244160.1 NP_001244163.1 NP_001244166.1 NP_001244170.1 NP_060936.1	n/a
Location (UCSC)	Chr X: 111.67 – 111.76 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.^[2][3]

Function

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.^[2][4]

See also

• Congenital disorder of glycosylation

References

1. "Human PubMed Reference:".
2. "Entrez Gene: asparagine-linked glycosylation 13 homolog (S. cerevisiae)".
3. Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N (October 2005). "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation". J. Biol. Chem. 280 (43): 36254–62. doi:10.1074/jbc.M507569200. PMID 16100110.
4. Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.

Further reading

• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mizuochi T, Matthews TJ, Kato M, et al. (1990). "Diversity of oligosaccharide structures on the envelope glycoprotein gp 120 of human immunodeficiency virus 1 from the lymphoblastoid cell line H9. Presence of complex-type oligosaccharides with bisecting N-acetylglucosamine residues.". J. Biol. Chem. 265 (15): 8519–24. PMID 2341393.
• Shimizu H, Tsuchie H, Honma H, et al. (1990). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
• Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer.". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes.". Hum. Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.