AOC2

AOC2
Identifiers
Aliases	AOC2, DAO2, RAO, amine oxidase, copper containing 2
External IDs	MGI: 2668431 HomoloGene: 56457 GeneCards: AOC2
Gene ontology Molecular function • electron carrier activity • tryptamine:oxygen oxidoreductase (deaminating) activity • aliphatic-amine oxidase activity • oxidoreductase activity • phenethylamine:oxygen oxidoreductase (deaminating) activity • copper ion binding • metal ion binding • quinone binding • aminoacetone:oxygen oxidoreductase(deaminating) activity • primary amine oxidase activity Cellular component • cytoplasm • plasma membrane • membrane Biological process • xenobiotic metabolic process • amine metabolic process • oxidation-reduction process • catecholamine metabolic process • visual perception Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	314	237940
Ensembl	ENSG00000131480	ENSMUSG00000078651
UniProt	O75106	Q812C9
RefSeq (mRNA)	NM_009590 NM_001158	NM_178932
RefSeq (protein)	NP_001149.2 NP_033720.2	NP_849263.1
Location (UCSC)	Chr 17: 42.84 – 42.85 Mb	Chr 11: 101.33 – 101.33 Mb
PubMed search	[1]	[2]
Wikidata

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Amine oxidase, copper containing 2 is a protein that in humans is encoded by the AOC2 gene.^[3]

Function

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Amine oxidase, copper containing 2". Retrieved 2015-12-31.

Further Reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.