AP1G2

AP1G2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9G, 2YMT, 3ZHF, 4BCX
Identifiers
Aliases	AP1G2, G2AD, adaptor related protein complex 1 gamma 2 subunit
External IDs	MGI: 1328307 HomoloGene: 49141 GeneCards: AP1G2
Gene ontology Molecular function • protein transporter activity • protein binding Cellular component • Golgi-associated vesicle • AP-1 adaptor complex • membrane coat • Golgi membrane • endosome • Golgi apparatus • endosome membrane • transport vesicle • membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • clathrin adaptor complex Biological process • protein transport • intracellular protein transport • viral process • vesicle-mediated transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8906	11766
Ensembl	ENSG00000213983	ENSMUSG00000040701
UniProt	O75843	O88512
RefSeq (mRNA)	NM_001282474 NM_001282475 NM_003917 NM_080545	NM_007455 NM_001303502
RefSeq (protein)	NP_003908.1	NP_031481.2
Location (UCSC)	Chr 14: 23.56 – 23.57 Mb	Chr 14: 55.1 – 55.11 Mb
PubMed search	[1]	[2]
Wikidata

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AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.^[3][4][5]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.^[5]

Interactions

AP1G2 has been shown to interact with NEDD4.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
4. Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2-3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922.
5. "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit".
6. Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. United States. 283 (46): 32119–30. doi:10.1074/jbc.M802632200. ISSN 0021-9258. PMID 18772139.

Further reading

• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. doi:10.1073/pnas.95.19.11229. PMC 21624. PMID 9736718.
• Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.". Curr. Biol. 8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID 9811606.
• Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.". Curr. Biol. 8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.". J. Virol. 73 (2): 1350–61. PMC 103959. PMID 9882340.
• Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin.". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
• Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter].". J. Virol. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
• Hartmann-Stühler C, Prange R (2001). "Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein.". J. Virol. 75 (11): 5343–51. doi:10.1128/JVI.75.11.5343-5351.2001. PMC 114939. PMID 11333915.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Janvier K, Craig H, Hitchin D, et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes.". J. Biol. Chem. 278 (10): 8725–32. doi:10.1074/jbc.M210115200. PMID 12486136.
• Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
• Mattera R, Ritter B, Sidhu SS, et al. (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains.". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Coleman SH, Van Damme N, Day JR, et al. (2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes.". J. Virol. 79 (4): 2066–78. doi:10.1128/JVI.79.4.2066-2078.2005. PMC 546596. PMID 15681409.