ATP11B

ATP11B
Identifiers
Aliases	ATP11B, ATPIF, ATPIR, ATPase phospholipid transporting 11B (putative)
External IDs	MGI: 1923545 HomoloGene: 32919 GeneCards: ATP11B
Gene ontology Molecular function • nucleotide binding • ion transmembrane transporter activity • metal ion binding • protein binding • phospholipid-translocating ATPase activity • hydrolase activity • ATP binding • magnesium ion binding Cellular component • integral component of membrane • recycling endosome • endosome • Golgi apparatus • membrane • plasma membrane • nuclear inner membrane • recycling endosome membrane • early endosome • endoplasmic reticulum Biological process • lipid transport • aminophospholipid transport • phospholipid transport • ion transport • ion transmembrane transport • phospholipid translocation • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23200	76295
Ensembl	ENSG00000058063	ENSMUSG00000037400
UniProt	Q9Y2G3	n/a
RefSeq (mRNA)	NM_014616	NM_029570
RefSeq (protein)	NP_055431.1	n/a
Location (UCSC)	Chr 3: 182.79 – 182.92 Mb	Chr 3: 35.75 – 35.86 Mb
PubMed search	[1]	[2]
Wikidata

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Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.^[3][4][5]

Function

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
4. Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Nov 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. PMID 11015572.
5. "Entrez Gene: ATP11B ATPase, Class VI, type 11B".

Further reading

• Halleck MS, Schlegel RA, Williamson PL (Mar 2002). "Reanalysis of ATP11B, a type IV P-type ATPase". The Journal of Biological Chemistry. 277 (12): 9736–40. doi:10.1074/jbc.M200240200. PMID 11790799.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.