ATP5G1

ATP5G1
Identifiers
Aliases	ATP5G1, ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9)
External IDs	MGI: 107653 HomoloGene: 38017 GeneCards: ATP5G1
Gene ontology Molecular function • lipid binding • transporter activity • hydrogen ion transmembrane transporter activity • protein binding Cellular component • proton-transporting ATP synthase complex, coupling factor F(o) • membrane • integral component of membrane • mitochondrion • mitochondrial membrane • proton-transporting two-sector ATPase complex, proton-transporting domain • mitochondrial inner membrane • mitochondrial proton-transporting ATP synthase complex Biological process • ATP synthesis coupled proton transport • ion transport • mitochondrial ATP synthesis coupled proton transport • ATP hydrolysis coupled proton transport • transport • proton transport • ATP biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	516	11951
Ensembl	ENSG00000159199	ENSMUSG00000006057
UniProt	P05496	Q9CR84
RefSeq (mRNA)	NM_005175 NM_001002027	NM_001161419 NM_007506
RefSeq (protein)	NP_001002027.1 NP_005166.1	NP_001154891.1 NP_031532.2
Location (UCSC)	Chr 17: 48.89 – 48.9 Mb	Chr 11: 96.07 – 96.08 Mb
PubMed search	[1]	[2]
Wikidata

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ATP synthase lipid-binding protein, mitochondrial is an enzyme that in humans is encoded by the ATP5G1 gene.^[3][4]

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dyer MR, Walker JE (Jul 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". The Biochemical Journal. 293 (Pt 1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
4. "Entrez Gene: ATP5G1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)".

Further reading

• Farrell LB, Nagley P (May 1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochemical and Biophysical Research Communications. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
• Yan WL, Lerner TJ, Haines JL, Gusella JF (Nov 1994). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
• Higuti T, Kawamura Y, Kuroiwa K, Miyazaki S, Tsujita H (Apr 1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochimica et Biophysica Acta. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Elston T, Wang H, Oster G (Jan 1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
• Wang H, Oster G (Nov 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Cross RL (Jan 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Wang HL, Zhu ZM, Yerle M, Wu X, Wang H, Yang SL, Li K (2005). "Full-length coding sequences and mapping of porcine ATP6VOE and ATP5G1 genes". Cytogenetic and Genome Research. 109 (4): 533. doi:10.1159/000084223. PMID 15906478.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.