ATP5G3

ATP5G3
Identifiers
Aliases	ATP5G3, P3, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)
External IDs	MGI: 2442035 HomoloGene: 133873 GeneCards: ATP5G3
Gene ontology Molecular function • transporter activity • hydrogen ion transmembrane transporter activity • lipid binding Cellular component • integral component of membrane • proton-transporting two-sector ATPase complex, proton-transporting domain • mitochondrial proton-transporting ATP synthase complex • membrane • mitochondrial membrane • mitochondrial outer membrane • mitochondrion • proton-transporting ATP synthase complex, coupling factor F(o) Biological process • mitochondrial ATP synthesis coupled proton transport • ion transport • proton transport • transport • ATP synthesis coupled proton transport • ATP hydrolysis coupled proton transport • ATP biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	518	228033
Ensembl	ENSG00000154518	ENSMUSG00000018770
UniProt	P48201	P56384
RefSeq (mRNA)	NM_001689 NM_001002258 NM_001190329	NM_001301721 NM_001301722 NM_175015
RefSeq (protein)	NP_001002258.1 NP_001680.1	NP_001288650.1 NP_778180.1
Location (UCSC)	Chr 2: 175.18 – 175.18 Mb	Chr 2: 73.91 – 73.91 Mb
PubMed search	[1]	[2]
Wikidata

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ATP synthase lipid-binding protein, mitochondrial is an enzyme that in humans is encoded by the ATP5G3 gene.^[3][4]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yan WL, Lerner TJ, Haines JL, Gusella JF (May 1995). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
4. "Entrez Gene: ATP5G3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)".

Further reading

• Farrell LB, Nagley P (1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.". Biochem. Biophys. Res. Commun. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
• Dyer MR, Walker JE (1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.". Biochem. J. 293 (1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
• Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
• Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.