ATP6AP1

ATP6AP1
Identifiers
Aliases	ATP6AP1, 16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3, ATPase H+ transporting accessory protein 1
External IDs	MGI: 109629 HomoloGene: 914 GeneCards: ATP6AP1
Gene ontology Molecular function • nucleotide binding • proton-transporting ATP synthase activity, rotational mechanism • transporter activity • proton-transporting ATPase activity, rotational mechanism • Rab GTPase binding • ATP binding Cellular component • integral component of membrane • proton-transporting V-type ATPase, V1 domain • membrane • vacuolar membrane • proton-transporting two-sector ATPase complex • vacuole • endosome membrane • extracellular exosome Biological process • insulin receptor signaling pathway • transferrin transport • pH reduction • ion transport • positive regulation of bone resorption • proton transport • positive regulation of osteoclast development • establishment of organelle localization • ion transmembrane transport • positive regulation of osteoblast differentiation • positive regulation of ERK1 and ERK2 cascade • transport • positive regulation of exocytosis • ATP hydrolysis coupled proton transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	537	54411
Ensembl	ENSG00000071553	ENSMUSG00000019087
UniProt	Q15904	Q9R1Q9
RefSeq (mRNA)	NM_001183	NM_018794
RefSeq (protein)	NP_001174.2	NP_061264.1
Location (UCSC)	Chr X: 154.43 – 154.44 Mb	Chr X: 74.3 – 74.3 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.^[3][4][5]

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V₁, (site of the ATP catalytic site) and a transmembrane, V₀, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (Jun 1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
4. Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (Feb 1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum Mol Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID 8281148.
5. "Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1".

Further reading

• Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes.". Biochem. J. 324 (3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
• Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase.". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
• Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases.". Physiol. Rev. 79 (2): 361–85. PMID 10221984.
• Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases.". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
• Kane PM (1999). "Introduction: V-ATPases 1992-1998.". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
• Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases.". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
• Yokoi H, Hadano S, Kogi M, et al. (1994). "Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection.". Genomics. 20 (3): 404–11. doi:10.1006/geno.1994.1194. PMID 8034313.
• Holthuis JC, Jansen EJ, Schoonderwoert VT, et al. (1999). "Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary.". Eur. J. Biochem. 262 (2): 484–91. doi:10.1046/j.1432-1327.1999.00396.x. PMID 10336633.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Bagai S, Rubio E, Cheng JF, et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells.". J. Biol. Chem. 277 (26): 23828–37. doi:10.1074/jbc.M201658200. PMID 11923311.
• Hodi FS, Schmollinger JC, Soiffer RJ, et al. (2002). "ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6919–24. doi:10.1073/pnas.102025999. PMC 124504. PMID 11983866.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.